DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrch2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_006528851.3	Gene:	Lrch2 / 210297	MGIID:	2147870	Length:	824	Species:	Mus musculus

Alignment Length:	683	Identity:	150/683 - (21%)
Similarity:	242/683 - (35%)	Gaps:	209/683 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQL 174
            :...|...:.:.|.....|.:.|...|:....|.:|:|......||:|.|..|.:|.:||.|..|
Mouse   125 ILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNL 189

  Fly   175 TKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNE 239
            ..|..|::..|.:..||.||..|| |..|.:.:|:|..:|.|:|.|..|..||||.|.::.||.:
Mouse   190 QMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDVSCNEIQVLPQQ 253

  Fly   240 ISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLD--QNRLQRLNDTLGNCENMQELILTENFL 302
            :..|.||.:|::.:|.|..|||   :|..|.::|||  .|::..:........::|.:||..|.|
Mouse   254 MGKLHSLKELNIRRNNLHVLPD---ELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPL 315

  Fly   303 SELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVS 367
            ...||.|....|:       :..:|  |.|..|.          ::.|.|..|.
Mouse   316 QVPPAQICLKGKV-------HIFKY--LNIQACC----------RMDKKPDSLD----------- 350

  Fly   368 GNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLE 432
                  ||             |.|:..|   .||.||:...       ..|.:.:.|     |..
Mouse   351 ------LP-------------SLNKRMP---SQPLTDSMED-------FYPNKNHGP-----DSG 381

  Fly   433 SDSEPFEER----EPS--RTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491
            ..|:..|:|    |||  .|:...|:.:...:|                       :.|||:.|.
Mouse   382 IGSDNGEKRLSTTEPSDDDTISLHSQVSESNRE-----------------------QTSRNDSHI 423

  Fly   492 NLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQ 556
                    .|:|                    |..|       |...|...:.|.|..||..
Mouse   424 --------TGSK--------------------PDSQ-------KDQEVYDFIDPNTEDVAVP--- 450

  Fly   557 GGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQV--EGEDDDFYK 619
              .||.:.        ..:.|:.|......|::.|.::|..:|.:.|:.   |:  |.||||..:
Mouse   451 --EEGDTH--------IGSFVSFLKGKEKSSEKSQKNEEPPNEKKVDKE---QLLPEEEDDDLKE 502

  Fly   620 --------------------RP--------PKLHRRDTPHHLKNKRVQHLTD------KQASEIL 650
                                ||        .||.:|......|::.:.|.|.      ||..| .
Mouse   503 VTDLRKIAAQLLKQEQKNRWRPLSYRTSFSDKLFQRTRAAGRKSRILNHSTSVMRNKLKQTVE-C 566

  Fly   651 ANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQE-----------------QQQQQQQHPFD 698
            ..::.:.|.|.     .||.....|:|.::...|:|:                 :|.:::...:.
Mouse   567 EKSVPADEGNS-----PLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKEYFKYK 626

  Fly   699 SSLSPISAGKTAEASTDPDNLDGVTELRLEQYE 731
            |:....|..:..|..:|..::...:.:..|:|:
Mouse   627 STRKNSSGNENEEQESDNAHMSAQSPVSSEEYD 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	58/174 (33%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	5/27 (19%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	3/19 (16%)
		LRR_8	129..187	CDD:290566	18/57 (32%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	22/57 (39%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	9/21 (43%)
		LRR_8	267..325	CDD:290566	14/59 (24%)
		leucine-rich repeat	269..289	CDD:275380	5/21 (24%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	4/21 (19%)
		LRR_4	337..375	CDD:289563	3/37 (8%)
		leucine-rich repeat	361..382	CDD:275380	2/20 (10%)
		PDZ	728..816	CDD:214570	2/4 (50%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrch2	XP_006528851.3	PRK15370	<101..>315	CDD:185268	62/193 (32%)
		leucine-rich repeat	125..145	CDD:275380	3/19 (16%)
		leucine-rich repeat	146..168	CDD:275380	5/21 (24%)
		leucine-rich repeat	169..191	CDD:275380	10/21 (48%)
		leucine-rich repeat	192..207	CDD:275380	4/14 (29%)
		leucine-rich repeat	214..236	CDD:275380	8/21 (38%)
		leucine-rich repeat	237..259	CDD:275380	9/21 (43%)
		leucine-rich repeat	260..280	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..304	CDD:275380	4/21 (19%)
		leucine-rich repeat	305..323	CDD:275380	7/17 (41%)
		CH_LRCH2	702..812	CDD:409120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910