DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Sntb1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_057876.1	Gene:	Sntb1 / 20649	MGIID:	101781	Length:	537	Species:	Mus musculus

Alignment Length:	444	Identity:	106/444 - (23%)
Similarity:	156/444 - (35%)	Gaps:	155/444 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 HPFDS-SLSPISAGKTAEASTD-----PDNLD----GVTELRLEQYEIHIERTAAGLGLSIAGGK 749
            ||... :.:|.|......|.||     |:::.    ||..|:.|         ..|||:||.|||
Mouse    75 HPVPGVAQAPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQE---------LGGLGISIKGGK 130

  Fly   750 -GSTPFKGDDDGIFISRVTEAGPAD-LAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVL 812
             ...|       |.||::.:...|| ...|.|||.::.|||..:.||.|.:|||.||..|..::|
Mouse   131 ENKMP-------ILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLL 188

  Fly   813 VVQ--REVTRLIGHPVFSEDGSVSQISVETRPLVA------DAPPAASIS-----HERYIPAPIE 864
            .|:  ||.|     |...:...||:|..||.|..:      .|.|.:|.|     ..:.||..:.
Mouse   189 EVKYMREAT-----PYVKKGSPVSEIGWETPPPESPRLGGGSAEPLSSQSFSFHRDRKSIPLKMC 248

  Fly   865 IVPQQQHLQQQQQQPIQQVAP----------------------THSYSGNVFATPTA-------- 899
            .|.:...|...:.:.::..:|                      .||.:|::.....|
Mouse   249 YVTRNMTLADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNAGDLLTRVVADIREQLGK 313

  Fly   900 ---------------AQTV--------QPA-VSAAPNGLLL-----NGREA---PL-SYIQLHTT 931
                           |:.|        :|| |......||:     ..:||   |: ||..|.|.
Mouse   314 TGIAGSREIRHLGWLAEKVPGESEKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHSYPLLATR 378

  Fly   932 LIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGG-----------------LAYRDGKIM 979
            |:..          ..|||||.     .|:.:|..|..|                 |::....|:
Mouse   379 LVHS----------GPGKGSPQ-----AGMDLSFATRTGTKQGIETHLFRAEISRDLSHWTRSIV 428

  Fly   980 VGDRVMAINGNDMTEA------------HHDAAVACLTEPQ--RFVRLVLQREY 1019
            .|....|....::|.|            |:|...:..||||  .|.:.::|..|
Mouse   429 QGCHNSAELTAEITTACTYRNQECRLTIHYDNGFSISTEPQDGAFPKTIIQSPY 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	33/91 (36%)
		PDZ_signaling	931..1016	CDD:238492	23/115 (20%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Sntb1	NP_057876.1	PDZ_signaling	110..191	CDD:238492	35/96 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..233		9/28 (32%)
		PHsplit_syntrophin	<241..298	CDD:269960	7/56 (13%)
		PH	322..429	CDD:365918	26/121 (21%)
		Calmodulin-binding. /evidence=ECO:0000250	517..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910