DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and dlg-1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001024431.1	Gene:	dlg-1 / 180819	WormBaseID:	WBGene00001006	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	982	Identity:	207/982 - (21%)
Similarity:	338/982 - (34%)	Gaps:	349/982 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 EVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKR--VQHLTDKQASEI-- 649
            |.:.|.|:..|.   |||..::||....:..||... ...:.::|.:..  :..|.|:.....
Worm    64 ERKSDAEKNMEV---RRVIERLEGGPHSYNSRPAAT-TSTSNYNLSSTTPLISDLRDRGGFSYLN 124

  Fly   650 ---LANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAE 711
               |.|.|.:...|         |.::||........:.:.|:|....            |...|
Worm   125 GGGLGNGLGNGLGN---------GLLSSPYNSSSTHYLHERQRQTSHD------------GTWRE 168

  Fly   712 AST----DPDNLD-------GVTELRLEQYEIH---IERTAAGLGLSIAGGKGSTPFKGDDDGIF 762
            .:|    .|..|:       ||.:....::|:.   :|:...|||.||.||. ..|.:..|..|:
Worm   169 TTTRTVDTPSGLERRVVEHTGVIDDHGRKWELENIVLEKGHTGLGFSITGGM-DQPTEDGDTSIY 232

  Fly   763 ISRVTEAGPADLAG-LKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQR---EVTRLIG 823
            ::.:.|.|.|...| ::..|.:..||.....:..|..||..||:.|.|:.|.::|   |....||
Worm   233 VTNIIEGGAALADGRMRKNDIITAVNNTNCENVKHEVAVNALKSSGNVVSLSLKRRKDEAFLPIG 297

  Fly   824 HPVFSEDGSVSQISVETRPLVADAPPAASISHERYIP-APIEIVPQQQHLQQQQQQPIQQVAPTH 887
            .   :..||.|.:.....|.|:    |.::.|..:.| |||...|.               .|.|
Worm   298 G---NFGGSTSYLRSGVTPSVS----AGNLQHAIHSPSAPIHPPPP---------------PPVH 340

  Fly   888 SYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSP 952
            ..|       .:..:|....|..||..:::              |::.  .:|||||||||:|:.
Worm   341 HGS-------LSQLSVGQYRSTRPNTSVID--------------LVKG--ARGLGFSIAGGQGNE 382

  Fly   953 PFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQR 1017
            ..|.|.| |::::|.|.|.|..||::.|||:::.::.:.:....|:.||..|......|||::|:
Worm   383 HVKGDTD-IYVTKIIEEGAAELDGRLRVGDKILEVDHHSLINTTHENAVNVLKNTGNRVRLLIQQ 446

  Fly  1018 EYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASI 1082
                        .:.|:.|..:...::                               ||.|.
Worm   447 ------------GTGAIFNDSASQQFM-------------------------------PTTPI-- 466

  Fly  1083 SNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSL 1147
                                                                            |
Worm   467 ----------------------------------------------------------------L 467

  Fly  1148 RPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTET 1212
            ||.:..|:...      ..|||..:....|.....|:                .||
Worm   468 RPSSVQDYNRS------QMGSQSHLSYGGPLNTSYSS----------------QAP--------- 501

  Fly  1213 ITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIV 1277
                              :|.||....|.|.|.|..|||:|:||.|:        || |:||.::
Worm   502 ------------------IAIPLEPRPVQLVKGQNGLGFNIVGGEDN--------EP-IYISFVL 539

  Fly  1278 PGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKA 1342
            |||:|...|.::.||.:|:||...:..|||::|...|...|:.:.||:|:.|......|..:.|.
Worm   540 PGGVADLSGNVKTGDVLLEVNGVVLRNATHKEAAEALRNAGNPVYLTLQYRPQEYQIFESKIEKL 604

  Fly  1343 EGERLGMHIKGGLNGQRGN-----PADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLL 1402
            ..:.:.....|.|:.:...     ..|||.|       |||..                  |..:
Worm   605 RNDVIAQSRMGTLSRKSEYVRALFDYDPSRE-------NSVAP------------------HRSM 644

  Fly  1403 GASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQ---------------------------A 1440
            |.::.|.::::.::.:|        :..:..:|..|:                           :
Worm   645 GFNYGDILHIINSSDDE--------WWTARKVHENGEETAEGVIPSKKRVEKRERLRRKQVNFNS 701

  Fly  1441 GGMSTGFNSSASCSGG--SRQGSRASETGSELSQSQS---VSSLD-----HEEDERLRQDFDVFA 1495
            |..|.|.|||.:   |  :|:|||     |:||.|:.   |.|.|     :||...:.:: .|::
Worm   702 GSQSLGRNSSTT---GLENRRGSR-----SQLSFSRKFPFVKSTDRLNDLNEESSNVAEE-PVWS 757

  Fly  1496 SQKPDAQ 1502
            .|..:.|
Worm   758 YQAVEQQ 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	27/91 (30%)
		PDZ_signaling	931..1016	CDD:238492	31/84 (37%)
		PDZ	1239..1329	CDD:214570	35/89 (39%)
		PDZ_signaling	1336..1425	CDD:238492	15/93 (16%)
dlg-1	NP_001024431.1	L27_1	7..63	CDD:312556
		PDZ	199..289	CDD:214570	28/90 (31%)
		PDZ_signaling	361..445	CDD:238492	31/100 (31%)
		PDZ	507..591	CDD:214570	35/92 (38%)
		SH3_DLG-like	623..684	CDD:212795	13/93 (14%)
		GuKc	776..944	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910