DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and mics-1

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001343863.1 Gene:mics-1 / 179475 WormBaseID:WBGene00011890 Length:293 Species:Caenorhabditis elegans


Alignment Length:259 Identity:68/259 - (26%)
Similarity:113/259 - (43%) Gaps:45/259 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   660 NDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTE 724
            :|...:|. :..|:||...:|             .|.||.|.:       |||:.|....|..|:
 Worm    16 SDPVYEHH-AALVSSPFHADE-------------DHTFDISFA-------AEATDDMTFNDTTTD 59

  Fly   725 ------LRLEQYE-IHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDK 782
                  :.||... :.||:|:.|.|.:|.||..:..|.| |.||::|.|.....: ...::.|||
 Worm    60 GNGQESVPLEALTVVEIEKTSKGFGFNIVGGTDNPHFVG-DIGIYVSSVNSESKS-YGVVRTGDK 122

  Fly   783 VIKVNGIVVVDADHYQAVQVLKA--CGAVLVLVVQREVTRLIGHPVFSEDGSVS---QISVETRP 842
            ::..:||.:....|.:||:|.::  .|.|..:::.||...|......:...|||   |::.:||.
 Worm   123 ILSFDGIDMTYKTHDEAVEVFRSVKIGHVAKMLIDREYLHLQEDRTQTPTASVSITPQVTPQTRS 187

  Fly   843 LVADAPPAASISHERY--------IPAPIEIVPQQQHLQQQQQQPIQQVAP-THSYSGNVFATP 897
            ...:.....|:||...        :.|.||.:..:.: :::..|.:...|| |||...:|..||
 Worm   188 TQNNTDTPKSMSHSESKSRLTSHGLSAVIERIRGKVY-EEEDAQSVTSYAPSTHSIIDDVPRTP 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380
LRR_8 84..138 CDD:290566
leucine-rich repeat 85..107 CDD:275380
leucine-rich repeat 108..130 CDD:275380
LRR_8 129..187 CDD:290566
leucine-rich repeat 131..153 CDD:275380
leucine-rich repeat 154..176 CDD:275380
leucine-rich repeat 177..199 CDD:275380
LRR_8 198..256 CDD:290566
leucine-rich repeat 200..222 CDD:275380
leucine-rich repeat 223..245 CDD:275380
LRR_8 267..325 CDD:290566
leucine-rich repeat 269..289 CDD:275380
leucine-rich repeat 292..314 CDD:275380
leucine-rich repeat 315..337 CDD:275380
LRR_4 337..375 CDD:289563
leucine-rich repeat 361..382 CDD:275380
PDZ 728..816 CDD:214570 27/90 (30%)
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
mics-1NP_001343863.1 PDZ_signaling 71..145 CDD:238492 24/75 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.