DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and soc-2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001293758.1	Gene:	soc-2 / 177286	WormBaseID:	WBGene00004929	Length:	631	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	144/492 - (29%)
Similarity:	220/492 - (44%)	Gaps:	78/492 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FKGCNR-QVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNE 71
            |..|.. |.:.:|.....:..:|..|...:: |.||||..|.:..||....:|..|:|||||:|.
Worm   139 FHKCKEAQDQRLDLSSIEITSIPSPIKELTQ-LTELFLYKNKLTCLPTEIGQLVNLKKLGLSENA 202

  Fly    72 IGRLPPDIQNFENLVELDVSRNDIPDIP-----------------------DDIKHLQSLQVADF 113
            :..||..:.:.|:|..||:..|.:.::|                       :.|.:|..|::.|.
Worm   203 LTSLPDSLASLESLETLDLRHNKLTEVPSVIYKIGSLETLWLRYNRIVAVDEQIGNLSKLKMLDV 267

  Fly   114 SSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLK 178
            ..|.|.:|||...:|.:|.|..::...||.:|.:.|....|..|:|:.|.|..||.:|.:|..|.
Worm   268 RENKIRELPSAIGKLTSLVVCLVSYNHLTRVPEEIGDCHSLTQLDLQHNDLSELPYSIGKLVNLV 332

  Fly   179 RLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPEL-------------------------- 217
            |:.:..|:|..:|..|.....|.|..::.|.||.|||.|
Worm   333 RIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLLTMLPKIHTVNLSRNELTAFPAGGPQ 397

  Fly   218 --------------------GLL---TKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEAL 259
                                |:.   |:||.|::.||.|..||.::....|:|:|:|:.|.|:.|
Worm   398 QFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELVSLPLDMGSWTSITELNLSTNQLKVL 462

  Fly   260 PDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNA 324
            |:.|.||..|.||.|..|:|::|.:.:||...::||.|.||.|..:|..||.:..|..|.|..|.
Worm   463 PEDIEKLVNLEILVLSNNQLKKLPNQIGNLNKLRELDLEENELETVPTEIGFLQHLTKLWVQSNK 527

  Fly   325 LEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLY-LPYSLVNLQLKAVWL 388
            :..||..||...:|..|.|.:|.|..:|.|:|:...|..|.::.|..|: ||:.|...|...:..
Worm   528 ILTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSLYLNDNSSLHNLPFELALCQSLEIMS 592

  Fly   389 SENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPI 425
            .||  .||....|:..| .|..::..||..|..|:.:
Worm   593 IEN--SPLSQIPPEITA-GGPSLVIQYLKMQGPYRGV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	95/342 (28%)
		leucine-rich repeat	18..38	CDD:275380	3/19 (16%)
		LRR_8	37..95	CDD:290566	23/57 (40%)
		leucine-rich repeat	39..61	CDD:275380	9/21 (43%)
		leucine-rich repeat	62..84	CDD:275380	9/21 (43%)
		LRR_8	84..138	CDD:290566	17/76 (22%)
		leucine-rich repeat	85..107	CDD:275380	7/44 (16%)
		leucine-rich repeat	108..130	CDD:275380	8/21 (38%)
		LRR_8	129..187	CDD:290566	18/57 (32%)
		leucine-rich repeat	131..153	CDD:275380	6/21 (29%)
		leucine-rich repeat	154..176	CDD:275380	9/21 (43%)
		leucine-rich repeat	177..199	CDD:275380	6/21 (29%)
		LRR_8	198..256	CDD:290566	24/106 (23%)
		leucine-rich repeat	200..222	CDD:275380	10/70 (14%)
		leucine-rich repeat	223..245	CDD:275380	8/21 (38%)
		LRR_8	267..325	CDD:290566	22/57 (39%)
		leucine-rich repeat	269..289	CDD:275380	8/19 (42%)
		leucine-rich repeat	292..314	CDD:275380	9/21 (43%)
		leucine-rich repeat	315..337	CDD:275380	8/21 (38%)
		LRR_4	337..375	CDD:289563	12/38 (32%)
		leucine-rich repeat	361..382	CDD:275380	7/21 (33%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
soc-2	NP_001293758.1	leucine-rich repeat	148..169	CDD:275380	3/20 (15%)
		leucine-rich repeat	170..192	CDD:275380	9/21 (43%)
		LRR_RI	<192..274	CDD:238064	21/81 (26%)
		LRR_8	192..249	CDD:290566	15/56 (27%)
		leucine-rich repeat	193..215	CDD:275380	9/21 (43%)
		leucine-rich repeat	216..238	CDD:275380	5/21 (24%)
		LRR_8	238..318	CDD:290566	20/79 (25%)
		leucine-rich repeat	239..261	CDD:275380	2/21 (10%)
		leucine-rich repeat	262..284	CDD:275380	8/21 (38%)
		leucine-rich repeat	285..307	CDD:275380	6/21 (29%)
		leucine-rich repeat	308..330	CDD:275380	9/21 (43%)
		LRR_RI	327..553	CDD:238064	68/225 (30%)
		leucine-rich repeat	331..353	CDD:275380	6/21 (29%)
		leucine-rich repeat	354..375	CDD:275380	9/20 (45%)
		leucine-rich repeat	402..425	CDD:275380	1/22 (5%)
		leucine-rich repeat	449..471	CDD:275380	10/21 (48%)
		leucine-rich repeat	472..517	CDD:275380	18/44 (41%)
		LRR_8	517..572	CDD:290566	18/54 (33%)
		leucine-rich repeat	541..563	CDD:275380	8/21 (38%)
		leucine-rich repeat	588..611	CDD:275380	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910