DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and fars-3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_495785.1	Gene:	fars-3 / 174351	WormBaseID:	WBGene00001498	Length:	591	Species:	Caenorhabditis elegans

Alignment Length:	244	Identity:	53/244 - (21%)
Similarity:	85/244 - (34%)	Gaps:	50/244 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1997 INAEKRASWRAARLRSLEQGAVEAQDVIKNMRKMTD------DLITHESRASEVETCKERIISLE 2055
            |.:||.|..:       |||...|.|:........|      ||::.|..|..:...|:.|.|..
Worm    38 ITSEKAAVEK-------EQGTRAASDLNDQEVYKIDIPANRYDLLSVEGLARAIRIFKQEIPSPA 95

  Fly  2056 LQVPETEDEG------KLDDTQPPLELEADDFQDDEDDDDDDDDEDDFEDEDEEEDTASIVTVQA 2114
            .:..:....|      |.:..|....:.....:|...|.|......|.:|:..:........|..
Worm    96 YKYADVPKTGLQKIIVKKETAQVRPFVVGAVLRDISFDADSYASFIDLQDKLHQNICRKRTLVAI 160

  Fly  2115 NNEKLFLRHDSDT-YGPSSIESVASGKVRIKPTPLSLHQTLAKETTIVEVLNPVIGGDGSARTIH 2178
            ..      ||.|| .||....:.|...::.||    |:||  ||.|..|::. :...|.     |
Worm   161 GT------HDLDTIQGPFEYRAEAPKDIKFKP----LNQT--KEYTAEELMT-LYSTDS-----H 207

  Fly  2179 VSGGLPFDED------AFEQGAVAVLRSETFVLPGAAGGGRSELSLNAK 2221
            :...||..::      .:::..|..      .:|....|..|:::||.|
Worm   208 LKAYLPIIQNHPVYPVIYDKNGVVC------SMPPIINGEHSKITLNTK 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
fars-3	NP_495785.1	PLN02265	1..591	CDD:215149	53/244 (22%)
		B3_4	119..280	CDD:214876	33/156 (21%)
		B5	315..375	CDD:281482
		PheRS_beta_core	393..590	CDD:238392
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910