DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and ZK546.2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_740983.2	Gene:	ZK546.2 / 173855	WormBaseID:	WBGene00022759	Length:	485	Species:	Caenorhabditis elegans

Alignment Length:	449	Identity:	115/449 - (25%)
Similarity:	176/449 - (39%)	Gaps:	149/449 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 TLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDH 207
            |:.|...:.::...|.|:|:.|..:|:.:..||.||.||:..|.:..|||::|.:..|..|.|..
Worm     9 TVRARLANASKTRVLSLKESALHRIPDDVKDLTMLKHLDMSINYLTQLPPFIGSMSHLKNLNLSR 73

  Fly   208 NQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLD---------------------- 250
            |||:.||.|:..|..|..|:||:|:|.||| ::|..|||..::
Worm    74 NQLESLPLEINSLACLEVLNVSQNKLTELP-DLSQCVSLKTVEAIENQFIIFPAGVCKCPNLETC 137

  Fly   251 -LAQNLLEALPDGIAKLSRLTILKLDQNRLQRLND-TLGNCE----------------------- 290
             |.:|.:|.|||.|..|..:::: |::|||..||. .|..||
Worm   138 LLTENRIEKLPDEIHSLRAISVI-LNKNRLLSLNTANLLRCERLRAVNVDDNQLNRDEIEQFLVN 201

  Fly   291 -------------------NMQE------------------------------------------ 294
                               ::||
Worm   202 APREIRISFERNVSQMHTTDLQEMGNDSSKTKSIGDNARKIIGKSGPSTSTVNKHLEMASKSRIL 266

  Fly   295 -----------------------LILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCA 336
                                   |.|:||.:.|:|..|||.::|..|::..|.||:||.|:|...
Worm   267 QLKGTGLKKVPDEIEPLADVLRNLELSENKIREIPIFIGQFSQLKQLHLANNCLEFLPDELGSMK 331

  Fly   337 NLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVN-LQLKAVWLSENQSQPLLTFQ 400
            .|.:|:|..||||.||..:..||.|..:|:|.|.....|.:::. |||..:.|:.||.:.|
Worm   332 KLEILNLAGNKLKALPDTIVGCTDLKTIDLSSNVFTVFPVAVIGCLQLDILNLNGNQIESL---- 392

  Fly   401 PDTDAETGEQVLSCYLLPQQEYQPITPA--------RDLESDSEPFEEREPSRTVVKFS 451
            ||..:......||   |.|.....:.|:        |.|..|....|:.|.:|.:::.|
Worm   393 PDDISNLKVIELS---LNQNRLSSLNPSNLAKTTRLRTLRLDENCLEKSEFTRDLLESS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	53/162 (33%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566	14/43 (33%)
		leucine-rich repeat	131..153	CDD:275380	2/9 (22%)
		leucine-rich repeat	154..176	CDD:275380	6/21 (29%)
		leucine-rich repeat	177..199	CDD:275380	9/21 (43%)
		LRR_8	198..256	CDD:290566	25/80 (31%)
		leucine-rich repeat	200..222	CDD:275380	10/21 (48%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	23/165 (14%)
		leucine-rich repeat	269..289	CDD:275380	7/20 (35%)
		leucine-rich repeat	292..314	CDD:275380	11/86 (13%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	15/37 (41%)
		leucine-rich repeat	361..382	CDD:275380	5/21 (24%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
ZK546.2	NP_740983.2	leucine-rich repeat	20..42	CDD:275380	6/21 (29%)
		LRR_8	43..99	CDD:290566	24/55 (44%)
		leucine-rich repeat	43..65	CDD:275380	9/21 (43%)
		LRR_4	65..107	CDD:289563	19/42 (45%)
		leucine-rich repeat	66..88	CDD:275380	10/21 (48%)
		leucine-rich repeat	89..110	CDD:275380	10/21 (48%)
		leucine-rich repeat	111..133	CDD:275380	1/21 (5%)
		leucine-rich repeat	154..179	CDD:275380	9/25 (36%)
		LRR_RI	208..460	CDD:238064	57/248 (23%)
		leucine-rich repeat	264..286	CDD:275380	0/21 (0%)
		leucine-rich repeat	287..309	CDD:275380	9/21 (43%)
		LRR_8	308..364	CDD:290566	23/55 (42%)
		leucine-rich repeat	310..332	CDD:275380	9/21 (43%)
		leucine-rich repeat	333..355	CDD:275380	10/21 (48%)
		leucine-rich repeat	356..378	CDD:275380	5/21 (24%)
		LRR_8	378..433	CDD:290566	16/61 (26%)
		leucine-rich repeat	379..398	CDD:275380	7/22 (32%)
		leucine-rich repeat	399..424	CDD:275380	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910