DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and egg-6

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_492348.1 Gene:egg-6 / 172670 WormBaseID:WBGene00010621 Length:961 Species:Caenorhabditis elegans


Alignment Length:1015 Identity:210/1015 - (20%)
Similarity:356/1015 - (35%) Gaps:281/1015 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 VEFVDKRHCSLPQVP------------------EEILRYSRTLEELFLDANH--------IRDLP 53
            :.|:.....:.|::|                  |::...::|:....:|..|        |..||
 Worm    13 IAFLSSAEITCPRIPEKCDCKISKSMIILSCNGEDVKTIAQTVGTSQIDELHILNGTDVKIESLP 77

  Fly    54 KNFFRLHRLRKLGLSDNEIGRLPPDI-QNFENLVE-LDVSRNDIPDIPDDIKHLQSLQVADFSSN 116
            .|     .||.:.:.::.:....|.. ::.|..:| :.::.|::..:| ...:|.:|...:.:||
 Worm    78 FN-----GLRTIAILNSTLQSFSPTAWRHVEATIEHITINGNELKTVP-VFGNLSTLMSMNLNSN 136

  Fly   117 PIPKLP-SGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLES----LELRENLLKHLP-ETISQLT 175
            .|..:| ..|:.|..||.|.|.:.::...|..  ||..:::    |::..|.|..:| :.:....
 Worm   137 QISSIPDKAFNGLSALTQLRLENNAICDFPPK--SLDAVKASLVLLDVSGNCLDAIPAQILRNAA 199

  Fly   176 KLKRLDLGDNEIEDLPPY-LGYLPGLHELWLDHNQLQRLPPELGL-LTKLTYLDVSENRLEELP- 237
            .|..||||.|.|.::..: |..||.|.||.:.:|.|:|:.|...: :.:|.||.:.:|.:..|. 
 Worm   200 NLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTLRRIHPMAFMNVPQLQYLYLQDNIISTLDG 264

  Fly   238 NEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTL--GNCENMQELILTEN 300
            |.:.|..:|..||::.|.|.||| .:..|..|..:::|.|.:.:: :||  .|..|:|.:.:..|
 Worm   265 NRLQGFKNLEVLDVSNNALYALP-SLKDLPNLKQVRVDGNLITKI-ETLAFSNNPNLQLISVQNN 327

  Fly   301 FLSELPA-SIGQMTKLNNLNVDRNALEYLPLEIGQ---CANLGVLSLRDNKLKKLP----PELGN 357
            .:.::.. |...:.||..|.|..|:|  ..:|.|.   ..||..||:|:|.|..|.    .:|.:
 Worm   328 NIVQISRNSFESLDKLVVLLVGNNSL--AKIERGMFDGMKNLQQLSIRNNTLTALDASSFAQLAH 390

  Fly   358 CTVLHV---------------------LDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQP 401
            .|.|.:                     ||:|.|::.....|:...::..:.|..||         
 Worm   391 LTTLDLGHNKIHDIEEGTFDKLSKLFWLDLSNNKISGFKTSVFKKKISNILLDGNQ--------- 446

  Fly   402 DTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEE------REPSRTVVKFSEEATQEKET 460
                      |.|                    .|.|.|      ....||.:.|.:|       
 Worm   447 ----------LIC--------------------DESFNEFLTYLIANKVRTFLPFQQE------- 474

  Fly   461 PFVRQNTPHP------KDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQ 519
              :..:.|..      |||..|        ..||      ||.|  |::|...|..    :|.|.
 Worm   475 --IMCHGPEKYAGVRLKDLMMK--------KANE------TLSE--GSRLLGVPQG----SNQHS 517

  Fly   520 QQPH--PVQQPIVGVNSKQPVVVGVVTPTTTTV------------APTGVQGGSEGASSTAN-NV 569
            ....  |...|:..:|......:.:|...|.|:            .|.|.     ||||..| |:
 Worm   518 LLSSFLPSLGPLGTLNGAGGAAIPLVNTLTNTIPALRSIPGFGGNIPVGT-----GASSVPNKNL 577

  Fly   570 KAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDD-DFYKRPPKLHR------- 626
            ..|.......|.....|...|..|.||  ...|...:...|.|..| |..|..|.:.:       
 Worm   578 NDAIEGFTGPLVRFATGGQPVASDIEQ--LIRSIPNMVVNVPGFGDIDLSKMDPTMIQYVLNGGQ 640

  Fly   627 -----RDTPHHLKNKRVQHLTDKQASEILANALASQER----NDTTPQHSLSGKVTS-------P 675
                 :.|...:..:.:..:....|:.:..|.:..||:    .|..|    ||.||.       |
 Worm   641 IPGIDKATLDKIVKQTMNKMHTAAAANLAGNPVEGQEKVLPPLDKLP----SGLVTQVMSGEPLP 701

  Fly   676 IEEEEQLEVEQEQQQQQQQHPFDSSLSPISA--GKTAEASTDPDNLD------------------ 720
            ...|.|.::..|....|..........|:.:  ..||....:|...|                  
 Worm   702 GLNENQTKIIMEYYTHQMPGMDGIPARPVESQGNTTANNMFNPAMFDLLKMLPPGYNLSKIPMEV 766

  Fly   721 -------GVTELRL--EQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPA---- 772
                   .|.::||  |....|.::....|....||....        .|.|..:.|..|.    
 Worm   767 IAAVTRGEVPDMRLLPEDLLEHFKQHTTSLTSMFAGATAK--------NISIEEILEKLPVFVRP 823

  Fly   773 DLAGLKVGDKVIKVNGIVVVDA---DHYQAVQVLKA-----CGAVLVLVV---------QREVTR 820
            :|:.....| :.::...:|::.   :.::.::::.|     .|||.|:|:         ||.:.:
 Worm   824 ELSTFVPYD-INELTSEMVLEQEQNERHRNIRIITAIALAFVGAVTVVVIIFFVNYTKKQRRLRK 887

  Fly   821 LI------------GHPVFSEDGSVSQISVETRPLVADAP 848
            .:            |....:|.|..|......||.:.:.|
 Worm   888 SLVYRSSPSSSGSSGQNAANESGRSSAAPSPIRPPLMNIP 927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 73/304 (24%)
leucine-rich repeat 18..38 CDD:275380 3/37 (8%)
LRR_8 37..95 CDD:290566 13/67 (19%)
leucine-rich repeat 39..61 CDD:275380 6/29 (21%)
leucine-rich repeat 62..84 CDD:275380 3/22 (14%)
LRR_8 84..138 CDD:290566 15/55 (27%)
leucine-rich repeat 85..107 CDD:275380 4/22 (18%)
leucine-rich repeat 108..130 CDD:275380 7/22 (32%)
LRR_8 129..187 CDD:290566 17/62 (27%)
leucine-rich repeat 131..153 CDD:275380 7/21 (33%)
leucine-rich repeat 154..176 CDD:275380 4/26 (15%)
leucine-rich repeat 177..199 CDD:275380 9/22 (41%)
LRR_8 198..256 CDD:290566 19/59 (32%)
leucine-rich repeat 200..222 CDD:275380 7/22 (32%)
leucine-rich repeat 223..245 CDD:275380 7/22 (32%)
LRR_8 267..325 CDD:290566 15/60 (25%)
leucine-rich repeat 269..289 CDD:275380 5/21 (24%)
leucine-rich repeat 292..314 CDD:275380 3/22 (14%)
leucine-rich repeat 315..337 CDD:275380 7/24 (29%)
LRR_4 337..375 CDD:289563 15/62 (24%)
leucine-rich repeat 361..382 CDD:275380 6/41 (15%)
PDZ 728..816 CDD:214570 18/108 (17%)
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
egg-6NP_492348.1 LRR_8 107..162 CDD:290566 15/55 (27%)
leucine-rich repeat 107..127 CDD:275380 4/20 (20%)
leucine-rich repeat 128..151 CDD:275380 7/22 (32%)
LRR_RI <144..281 CDD:238064 40/138 (29%)
leucine-rich repeat 152..200 CDD:275380 11/49 (22%)
LRR_8 176..233 CDD:290566 17/56 (30%)
leucine-rich repeat 201..224 CDD:275380 9/22 (41%)
LRR_8 225..283 CDD:290566 18/57 (32%)
leucine-rich repeat 225..248 CDD:275380 7/22 (32%)
LRR_RI <240..458 CDD:238064 59/260 (23%)
leucine-rich repeat 249..272 CDD:275380 7/22 (32%)
LRR_8 271..329 CDD:290566 18/59 (31%)
leucine-rich repeat 273..294 CDD:275380 9/21 (43%)
leucine-rich repeat 295..318 CDD:275380 6/23 (26%)
LRR_8 317..375 CDD:290566 17/59 (29%)
leucine-rich repeat 319..342 CDD:275380 3/22 (14%)
leucine-rich repeat 343..366 CDD:275380 7/24 (29%)
LRR_8 365..425 CDD:290566 15/59 (25%)
leucine-rich repeat 367..390 CDD:275380 8/22 (36%)
leucine-rich repeat 391..414 CDD:275380 2/22 (9%)
leucine-rich repeat 415..434 CDD:275380 5/18 (28%)
leucine-rich repeat 437..449 CDD:275378 4/30 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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