DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and lin-10

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_492226.2	Gene:	lin-10 / 172597	WormBaseID:	WBGene00002999	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	1172	Identity:	206/1172 - (17%)
Similarity:	371/1172 - (31%)	Gaps:	392/1172 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 ENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEA 454
            |.|..|.....|      |....:.:|.|   |.|...|...|.:::|         .:.||...
Worm    44 EQQQVPFQMIPP------GHFFANPFLNP---YIPTAGAPAQEGEAQP---------QMVFSPAQ 90

  Fly   455 TQEKETPFVRQ---------NTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTE 510
            .||....:.:|         ..|.|...:...|:.:.....:..|.:    .::||.:.|.:...
Worm    91 YQEVMHHYFQQMMAASGAQFPIPFPMQFQPALQQPRPSSQASSSHRS----EDDNGRQTAGSVVS 151

  Fly   511 TRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAA 575
            :....|:.:.:|        ..:|.:  ..|||......:.||          ||:::|
Worm   152 SNVSPNHREVRP--------AEDSTE--TSGVVQNNDELLVPT----------STSSDV------ 190

  Fly   576 VVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGED---------DDFYKRPPKLHRRDTPH 631
                   |:|  |.::..|..|:..||   .|.:.:.|:         |...::......::...
Worm   191 -------TIG--DVIEKSDSPENSQES---AGGEEKSEEKRKLSGDRTDSLIRKQMSEMEKEITR 243

  Fly   632 HLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSG-KVTSPIEEEEQLEVEQEQQQQQQQH 695
            ..:||.::.:.|...:|::..:......:|.:|....|| ..|:|
Worm   244 RSQNKNIKTIDDDGLAELIGGSSTRTVADDFSPFVDKSGLSYTAP-------------------- 288

  Fly   696 PFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDG 760
                  :|.|..|:|..       :.:.:||                         :.|...||.
Worm   289 ------APPSTEKSAPK-------ESLNQLR-------------------------SSFNLPDDS 315

  Fly   761 IFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIG-- 823
                  |..||...:.:....:....|.:.:.:|.::    |..|....:.:..|.......|
Worm   316 ------TTVGPVGPSTVPQQSQQFANNSMFMANAGNF----VQNAFPIGVTMTPQATFGAAPGFQ 370

  Fly   824 ------HPVFSEDGSVSQISVETRPLV------------ADAPPAASISHERYIPAPIEIVPQQQ 870
                  |.:|.:..:.:.::..|.|.:            ..||...::|.:::       .|:|.
Worm   371 MMQPHQHNLFMQQPNPTFVNNGTNPFLQTQATLPNFVQNGTAPLVPTVSAQQF-------TPEQL 428

  Fly   871 HLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLL-------------LNGREAP 922
            .....|||..|..|||      .|.:|..:   .|:.|:.|:|.|             ::|...|
Worm   429 AAAFAQQQIAQSAAPT------PFDSPPPS---MPSTSSGPSGALAPPPPPSHPIPRRVSGNGWP 484

  Fly   923 LSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDG-IFISRIT-------------EGGLAY 973
                       .:....|...|...|..|.|.....|. :::.|.:             |..:::
Worm   485 -----------EENKENGTSTSTTNGAQSVPAAAGTDDPVWVLRDSYLKKMQREQRTSEEEEMSW 538

  Fly   974 RDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLV---------LQREYRGPLE----- 1024
            ::......:......|:|..|...|             ||:         ...|.||.::
Worm   539 QEAATAAQEAAENGGGDDQEEQETD-------------RLLNGGTTGASTKGAERRGSVDKKKNS 590

  Fly  1025 PPTSPRSPAVL--NSLSPSGYL-------------ANRPANFSRSVVEVEQPYKYNTLATTTPTP 1074
            ..|....||||  ..|..:.||             |.|.|....:|..|:.|
Worm   591 KETMVHEPAVLIEGVLFRARYLGSTQMLCESRGSKAARMAQAQEAVARVKAP------------- 642

  Fly  1075 KPTVPASISNNNNTLPSSKTNGFATAAAATI---------DSSTGQPVPAPR--RTNSVPMGDGD 1128
                      ..:..||::.:.|.:.....:         |:...|.:....  ||.|.....||
Worm   643 ----------EGDVQPSTEIDLFISTEKIMVLNTDLQRISDTDVRQDILMDHALRTISYIADIGD 697

  Fly  1129 I------------GAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQV-----HVAR 1176
            :            ...|.:.|||                         |||...:.     ||..
Worm   698 LVVLMARRMSTSHSDESCSDGDS-------------------------SGGGVRKTPKVICHVFE 737

  Fly  1177 PNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQ---------LA 1232
            .:|....|.::.        ..|..|..|..|.......|...:.....:.::|         .|
Worm   738 SDEASFIAQSIG--------QAFQVAYVEFLRANGIDDPSYLRQIDYQEVLNSQELLGDELEMFA 794

  Fly  1233 EPLISEEVVLPKNQGS-LGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILK 1296
            :....:|||:||..|. ||..::..      .:|:..|.:.::|:.|.|.|:...||.:||:|:.
Worm   795 KKETQKEVVVPKKAGEPLGIVVVES------GWGSMLPTVVLAHMNPVGPAAHSNKLNIGDQIIN 853

  Fly  1297 VNEAD-----VSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGE-RLGMHIKGGL 1355
            :|...     :|.|..|   ::.:|....:::|:..   .|...||.:.:.:.: :||..::.|:
Worm   854 INGISLVGLPLSAAQTQ---IKNMKTATAVRMTVVS---TPPVVEVRIRRPDTKYQLGFSVQNGV 912

  Fly  1356 NGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEI 1420
                            :..:...|.|.|.| ::||.|::|:||.|::..:|...||:|..|..||
Worm   913 ----------------ICSLLRGGIAERGG-IRVGHRIIEINGTSVVAVAHDRIVNMLATAVGEI 960

  Fly  1421 QL 1422
            .:
Worm   961 HM 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	10/87 (11%)
		PDZ_signaling	931..1016	CDD:238492	14/107 (13%)
		PDZ	1239..1329	CDD:214570	25/95 (26%)
		PDZ_signaling	1336..1425	CDD:238492	23/88 (26%)
lin-10	NP_492226.2	PTB_X11	598..767	CDD:269919	38/224 (17%)
		PDZ_signaling	800..885	CDD:238492	25/93 (27%)
		PDZ_signaling	890..963	CDD:238492	23/90 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910