DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP011503

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_317796.3	Gene:	AgaP_AGAP011503 / 1278244	VectorBaseID:	AGAP011503	Length:	276	Species:	Anopheles gambiae

Alignment Length:	183	Identity:	56/183 - (30%)
Similarity:	78/183 - (42%)	Gaps:	43/183 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 TISQLTKLKRLDL-----------GDNEIEDLPPYLGYLPGLH-----------ELWLDHNQLQR 212
            |::::.::.|.|.           .||:            .||           .|.||:..|:|
Mosquito    71 TVAEIERILRFDQSNTVLFLFSSNSDNQ------------NLHTTFTVERNKLVRLSLDNAGLER 123

  Fly   213 LPPELGLL-----TKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP-DGIAKLSRLTI 271
            |  ||.||     .:|..|.|..|||.:||..:..|.:|..||.:.||||... |.:|..:.|..
Mosquito   124 L--ELTLLGRENDCRLADLSVPRNRLRDLPTGVERLTALRKLDYSYNLLEEFKLDRLANAAGLKQ 186

  Fly   272 LKLDQNRLQRLNDT-LGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRN 323
            |.|..|||:|...| ..|...:.:|.|:.|.|..|.||...|.:|...:||.|
Mosquito   187 LLLSHNRLERFVATEQVNLAALHKLDLSNNRLRALDASYWTMPQLETFHVDNN 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	42/140 (30%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566	5/27 (19%)
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380	1/5 (20%)
		leucine-rich repeat	177..199	CDD:275380	4/32 (13%)
		LRR_8	198..256	CDD:290566	25/73 (34%)
		leucine-rich repeat	200..222	CDD:275380	12/37 (32%)
		leucine-rich repeat	223..245	CDD:275380	9/21 (43%)
		LRR_8	267..325	CDD:290566	21/58 (36%)
		leucine-rich repeat	269..289	CDD:275380	8/20 (40%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	4/9 (44%)
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP011503	XP_317796.3	LRR	<97..>194	CDD:227223	35/110 (32%)
		leucine-rich repeat	111..136	CDD:275380	10/26 (38%)
		leucine-rich repeat	137..159	CDD:275380	9/21 (43%)
		LRR_8	160..218	CDD:290566	21/57 (37%)
		leucine-rich repeat	160..183	CDD:275380	9/22 (41%)
		leucine-rich repeat	184..207	CDD:275380	9/22 (41%)
		leucine-rich repeat	208..230	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910