DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and AgaP_AGAP000054

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:XP_311104.5 Gene:AgaP_AGAP000054 / 1272222 VectorBaseID:AGAP000054 Length:1593 Species:Anopheles gambiae


Alignment Length:1921 Identity:960/1921 - (49%)
Similarity:1150/1921 - (59%) Gaps:445/1921 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            |||.||||||||||:|:||.||.|||.|||||.|||.:||||.|||||||||||.||||:|||||
Mosquito     1 MFKYIPIFKGCNRQIEYVDNRHSSLPNVPEEIFRYSNSLEELLLDANHIRDLPKGFFRLYRLRKL 65

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||:|.::|.|||||.||||||||||:|.|||:|||||:|||:||||||||.:||:||:||:|
Mosquito    66 GLSDNDIIKIPSDIQNFVNLVELDVSRNEIGDIPEDIKHLRSLQIADFSSNPISRLPAGFTQLRN 130

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            |||||||||||.:||.|||.|::|.||||||||||:|||:|||||||:|||||||||::||.::|
Mosquito   131 LTVLGLNDMSLISLPQDFGCLSKLVSLELRENLLKNLPESISQLTKLERLDLGDNEIDELPSHVG 195

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            |||.|.|||||||||.|||||:|||.||..||||||||||||.||.||..||||.|:|||||.||
Mosquito   196 YLPSLQELWLDHNQLLRLPPEIGLLKKLVCLDVSENRLEELPEEIGGLECLTDLHLSQNLLETLP 260

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            :||:||:.|:|||||||||..|||::|.|.:||||||||||||||||::|.|..|||||||||:|
Mosquito   261 NGISKLTNLSILKLDQNRLHTLNDSIGCCVHMQELILTENFLSELPATVGNMLVLNNLNVDRNSL 325

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            ..:|.|:|.|..|||||||:|||.:||.|||||..|||||||||.|.:|||||||||||||||||
Mosquito   326 VAVPSELGNCRQLGVLSLRENKLTRLPAELGNCGELHVLDVSGNLLQHLPYSLVNLQLKAVWLSE 390

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRT-VVKFSEEA 454
            |||||:.|||||.|..|.||||:|:|||||.|.|..|::..::|||.:||||.||| .|||:|:.
Mosquito   391 NQSQPVPTFQPDVDETTNEQVLTCFLLPQQRYVPSNPSQREDTDSENWEEREASRTHSVKFTEDF 455

  Fly   455 TQEKETPFVRQNTPHPKDLKAKAQKL-KVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNH 518
            ..:::||||||||||||:||.||.|| ..||..::...||.||.||:.::        .::.|..
Mosquito   456 GADRDTPFVRQNTPHPKELKMKAHKLFAKERKSDDLSGNLDTLSEESASR--------PSLLNRS 512

  Fly   519 QQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAAT 583
                                  |..|.|...:....:....|...:.|.:.:|.           
Mosquito   513 ----------------------GYGTATMEDIQGHAIPHDEEQGEAAAGSAEAG----------- 544

  Fly   584 VGGSDEVQDDDEQEDEFESDRRVGFQV-EGEDDD----FY---------KRP-PKLHRRDTPHHL 633
             ||.:..|||   ||.:|  :||||:| |.||||    .|         |:| .|||||||||||
Mosquito   545 -GGVEGAQDD---EDGYE--KRVGFEVNEDEDDDPERQQYGEDGDEHGGKKPISKLHRRDTPHHL 603

  Fly   634 KNKRVQH-LTDKQASEILANALASQERN------------DTTPQHSLSGKVTS----------- 674
            |||||.| :|||. :.::.|:|..:|..            ...|..|:..||..           
Mosquito   604 KNKRVHHTITDKN-TNLMFNSLKLKEMTPPKLDEHPAMEPPVPPMFSVKFKVKDGGKGGPGRKGP 667

  Fly   675 --PIEEEEQLEVEQEQQQQQQQHPFDSSLS-------------------PISAGKTAEA------ 712
              |:...................|..|.||                   .:..|:|..|      
Mosquito   668 GRPLSRRSSGASSFRSSGTSGSLPPASILSSGKKKGGRKDDKRRIRIITAVKDGRTGPAGKGGGG 732

  Fly   713 ---------STDP---------DNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDD 759
                     |:.|         |.||..|.|:.|:.|||||||:||||||||||:|||||||||:
Mosquito   733 GGGTFALSSSSSPMFGKRKVYDDTLDTYTALKEERLEIHIERTSAGLGLSIAGGRGSTPFKGDDE 797

  Fly   760 GIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGH 824
            |||||||||.||||||||||||||:|||||.|.|||||.||:||||||:||:|.:.|||||||||
Mosquito   798 GIFISRVTERGPADLAGLKVGDKVLKVNGISVEDADHYDAVEVLKACGSVLILYIAREVTRLIGH 862

  Fly   825 PVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSY 889
            |||.:.|||:||||..:..:...|         .:.||:.:                   ||...
Mosquito   863 PVFDDTGSVAQISVSDQDALKPPP---------LVGAPLGL-------------------PTVDG 899

  Fly   890 SGNVFATPTAAQTVQPAVSAAPNG-----------LLLNGREAPLSYIQLHTTLIRDQIGQGLGF 943
            :|    .|.....:.|.....|||           .:.||.|.....| ||||||||||||||||
Mosquito   900 AG----VPPYMGALSPNTVGLPNGGAGGGVGGGALDMPNGNEITQKII-LHTTLIRDQIGQGLGF 959

  Fly   944 SIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQ 1008
            |||||||..||||..:||:|||:||.|:|::||||||||||:||||.|:|.||||.||..||:.|
Mosquito   960 SIAGGKGHAPFKDGSEGIYISRLTENGVAHKDGKIMVGDRVLAINGVDITNAHHDYAVQLLTDHQ 1024

  Fly  1009 RFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPT 1073
            ||||||:|||.:|||||..|||||.|    .|     |||                         
Mosquito  1025 RFVRLVVQREVKGPLEPLHSPRSPVV----GP-----NRP------------------------- 1055

  Fly  1074 PKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGD 1138
                                     .||||                                   
Mosquito  1056 -------------------------PAAAA----------------------------------- 1060

  Fly  1139 SGEAQPSSL-RPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAA 1202
             |...|:.| ||:||.|||||||:||:|||.: ||.|.: ::.|.| |||.|.|..||:||.|.|
Mosquito  1061 -GAYLPNRLARPMTSADFQAMIPSHFISGGGR-QVTVDK-SDHGPS-VTVTVQKAVPDMPMLPPA 1121

  Fly  1203 PTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTR 1267
            |||||.|||||||||||||                 ||:|||:||||||||||||||||.|||..
Mosquito  1122 PTELGTVTETITKSTFTET-----------------EVILPKDQGSLGFSIIGGTDHSCTPFGAN 1169

  Fly  1268 EPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPP 1332
            ||||||||||.||||:..|||||||||||||..||::||||:||:|||:|.|:||||:||||||.
Mosquito  1170 EPGIFISHIVAGGIAALSGKLRMGDRILKVNGTDVTQATHQEAVMELLRPCDDIKLTVQHDPLPA 1234

  Fly  1333 GFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVN 1397
            |||||.:.|.:|||||||||||||||||||.|.:|||||:||||:.|||:|||||:||||:||||
Mosquito  1235 GFQEVHIVKQDGERLGMHIKGGLNGQRGNPLDNADEGVFISKINANGAAKRDGRLRVGMRILEVN 1299

  Fly  1398 GHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSR 1462
            |.||||||||:||:.||.:|:::.|||||||:||:|:|..|.|||||||.:::..   .:|.|||
Mosquito  1300 GLSLLGASHQEAVDALRASGSKLHLVVCKGYEKSDLLHLAGSAGGMSTGLSNNGD---SARIGSR 1361

  Fly  1463 ASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPA 1527
            ||||||||  ||||||||.::...:.:.....:..|.|.:                  :.|..||
Mosquito  1362 ASETGSEL--SQSVSSLDRDDSVIMAEAHRKLSVDKIDEE------------------TLPPQPA 1406

  Fly  1528 ATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIV 1592
            ...:   ||         :..|:.|.:|  |||    ..:...||..:.|  :||||.||||:||
Mosquito  1407 VHDH---LP---------IDQPEPPTSQ--ALI----SVNPNDQQVAIGP--KEKSTPEKVLDIV 1451

  Fly  1593 RAADAFT-------TVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESA 1650
            |||::..       ..|||||:| ...:.:|||||:|:||||||                     
Mosquito  1452 RAAESLALGSQLVENGPPKSPTE-VASEPLQKTTTIVMSKHTLD--------------------- 1494

  Fly  1651 NSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAK 1715
                                                                             
Mosquito  1495 ----------------------------------------------------------------- 1494

  Fly  1716 PTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQEEERKIATLRRDKNSRL 1780
               |:.|:||||||||||:|||||.|||.|::|||||||:|||||||||||||||:|.:|   |:
Mosquito  1495 ---TQAPQSVSDKKRFFENAMEDQQKPTPKSEKVFSFLSQDEVEKLRQEEERKIASLGKD---RV 1553

  Fly  1781 LDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEE 1816
            .....|..|:|        :.|.|.|.|....|:.:
Mosquito  1554 HQRFGDEEDED--------DDNRSDGGDRPPGDKSD 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 206/269 (77%)
leucine-rich repeat 18..38 CDD:275380 15/19 (79%)
LRR_8 37..95 CDD:290566 46/57 (81%)
leucine-rich repeat 39..61 CDD:275380 19/21 (90%)
leucine-rich repeat 62..84 CDD:275380 16/21 (76%)
LRR_8 84..138 CDD:290566 43/53 (81%)
leucine-rich repeat 85..107 CDD:275380 18/21 (86%)
leucine-rich repeat 108..130 CDD:275380 16/21 (76%)
LRR_8 129..187 CDD:290566 46/57 (81%)
leucine-rich repeat 131..153 CDD:275380 17/21 (81%)
leucine-rich repeat 154..176 CDD:275380 18/21 (86%)
leucine-rich repeat 177..199 CDD:275380 15/21 (71%)
LRR_8 198..256 CDD:290566 44/57 (77%)
leucine-rich repeat 200..222 CDD:275380 18/21 (86%)
leucine-rich repeat 223..245 CDD:275380 17/21 (81%)
LRR_8 267..325 CDD:290566 42/57 (74%)
leucine-rich repeat 269..289 CDD:275380 14/19 (74%)
leucine-rich repeat 292..314 CDD:275380 18/21 (86%)
leucine-rich repeat 315..337 CDD:275380 14/21 (67%)
LRR_4 337..375 CDD:289563 27/37 (73%)
leucine-rich repeat 361..382 CDD:275380 17/20 (85%)
PDZ 728..816 CDD:214570 72/87 (83%)
PDZ_signaling 931..1016 CDD:238492 64/84 (76%)
PDZ 1239..1329 CDD:214570 70/89 (79%)
PDZ_signaling 1336..1425 CDD:238492 64/88 (73%)
AgaP_AGAP000054XP_311104.5 leucine-rich repeat 16..38 CDD:275380 16/21 (76%)
LRR_RI 23..259 CDD:238064 183/235 (78%)
LRR_8 38..95 CDD:290566 46/56 (82%)
leucine-rich repeat 39..58 CDD:275380 16/18 (89%)
leucine-rich repeat 62..84 CDD:275380 16/21 (76%)
LRR_8 84..138 CDD:290566 43/53 (81%)
leucine-rich repeat 85..107 CDD:275380 18/21 (86%)
leucine-rich repeat 108..130 CDD:275380 16/21 (76%)
leucine-rich repeat 131..176 CDD:275380 35/44 (80%)
LRR_8 152..210 CDD:290566 44/57 (77%)
leucine-rich repeat 177..199 CDD:275380 15/21 (71%)
LRR_8 198..256 CDD:290566 44/57 (77%)
leucine-rich repeat 200..222 CDD:275380 18/21 (86%)
leucine-rich repeat 223..245 CDD:275380 17/21 (81%)
LRR_8 246..300 CDD:290566 38/53 (72%)
leucine-rich repeat 246..268 CDD:275380 16/21 (76%)
LRR_8 315..371 CDD:290566 40/55 (73%)
leucine-rich repeat 315..337 CDD:275380 14/21 (67%)
leucine-rich repeat 361..382 CDD:275380 17/20 (85%)
PDZ 766..854 CDD:214570 72/87 (83%)
PDZ_signaling 943..1032 CDD:238492 68/89 (76%)
PDZ_signaling 1139..1228 CDD:238492 70/105 (67%)
PDZ_signaling 1238..1327 CDD:238492 64/88 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 352 1.000 Domainoid score I2753
eggNOG 1 0.900 - - E33208_3BA7S
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H136592
Inparanoid 1 1.050 1449 1.000 Inparanoid score I378
OMA 1 1.010 - - QHG48681
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 1 1.000 - - FOG0005473
OrthoInspector 1 1.000 - - otm51187
Panther 1 1.100 - - LDO PTHR23119
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5064
TreeFam 00.000 Not matched by this tool.
1211.980

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