DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP000452

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_310641.4	Gene:	AgaP_AGAP000452 / 1271787	VectorBaseID:	AGAP000452	Length:	1168	Species:	Anopheles gambiae

Alignment Length:	1297	Identity:	243/1297 - (18%)
Similarity:	390/1297 - (30%)	Gaps:	475/1297 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 EYQPITPARDLESDSE-----------PFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLK 474
            :|.|..|..:.||.:|           ..:...|:.||:...|.|..|.|          ||...
Mosquito    28 QYHPHDPYGERESAAELHFWDEPDGRGAHQNTTPASTVLHSPEPAPTEHE----------PKMRF 82

  Fly   475 AKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTI-------------ANNHQQQPHPVQ 526
            .:..:::|.||.       |.....||:  :::.|.:..:             |.:||.|....|
Mosquito    83 QQRHQIQVGRSP-------VGSGGHNGS--SDSTTASSPVLMPHCHHGPSAGGAQHHQLQQQQQQ 138

  Fly   527 QPIVGVNS----KQPVVVGVVTPTTTTVAPTGVQG---GSE-------GASSTANNVKAATAAVV 577
            |.:.|..|    .:.||...:.|..    |||..|   ||:       |...|..|.:..|.: .
Mosquito   139 QHVYGTQSILSDGEIVVFDDIEPNW----PTGTGGTVNGSDLSMLMGGGGGGTTPNKETHTDS-C 198

  Fly   578 AELAATVGG-----------------SDEVQDDDEQEDEFESDRRVGFQVEGE---------DDD 616
            .::...:||                 |....|.........|..|.||....|         ||.
Mosquito   199 TKIQTIIGGLTIAEYEGSPRRFGTIYSSSYADGGTIRPGGASFPRPGFPKRVEPSAAPYDQLDDG 263

  Fly   617 FYKRPPKLHRRDTP-----HHLKNKRVQHL-----------TDKQASEILANALASQ---ERNDT 662
               ||.::.....|     :::|:..|..|           .|....|:....|..|   .|:..
Mosquito   264 ---RPRQIELGKGPSETSFYNIKSNMVAELILIPELIPILDDDDPIQELTLIPLPKQIAIPRSIP 325

  Fly   663 TPQHSLSGKVTSPI-------------------------------------------------EE 678
            .|:..   .:|.||                                                 ..
Mosquito   326 IPEPI---SITKPILIPKLIPILDPIPIPKPIPILDPILIPILDLFPILILDLIPKPIPIPITAL 387

  Fly   679 EEQLEVEQEQQQQQQQHPFDSSLSPI-------SAGKTAEASTDPDNLD----GVTELRLEQYEI 732
            |..||...:|..:.:..|...:...:       |..:.:...||....|    |..|   |.:.|
Mosquito   388 ESTLEWAPDQTPESESIPASETAPELIPNTESESGSEMSAFQTDTKYYDRPQAGSLE---EDFTI 449

  Fly   733 HIERTAAGLG-----------LSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKV 786
                .|:|.|           :....|.|:..|......:...||.:.|..:..|
Mosquito   450 ----PASGTGRKPHSFALSPEMDYRSGCGTAEFGTTFRPVSYGRVQKPGGGNGTG---------- 500

  Fly   787 NGIVVVDADHYQAVQVLK--------ACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPL 843
                       :|.::|.        .|.::.:|    |.....||...||..:|:....:...|
Mosquito   501 -----------EAKEILNEPCVEYDDMCNSMPIL----EDGLSSGHASDSEGNTVANSCDQGGDL 550

  Fly   844 VADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVS 908
            :|:    .|:.           :...:|.|.||||..||....|                  |..
Mosquito   551 MAN----GSLG-----------MQSMRHQQDQQQQQQQQHYHHH------------------AAL 582

  Fly   909 AAPNG-----LLLNGREAPLSYIQ--LHTTLI-------RDQIGQGL-GFSIAGGKGSPPFKDDC 958
            ..|||     .|.|.....|:.|:  |..|..       ||...||. |...|...|      |.
Mosquito   583 DGPNGAGISDCLANDIRDALNDIKSTLQNTKALPTGDERRDSADQGCRGEPFAHSYG------DV 641

  Fly   959 DGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPL 1023
            ..:::.|.       |||.               .|..|.:| |.||:         ||....|.
Mosquito   642 SPVWVLRT-------RDGS---------------PEQEHPSA-AHLTD---------QRHGNPPP 674

  Fly  1024 EPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQP--YKYNTLATTTPTPKPT--------- 1077
            .|.....:...|.:....|:...:.:...       :|  |::|..|......||.
Mosquito   675 PPDLEEETDTDLETDRLLGHQQQQQSGGG-------EPSYYEHNNAADVGGVGKPKSPNSAMLAK 732

  Fly  1078 ---------------VPASISNNNNTLPSSKTNGFATAAAATIDSST------------------ 1109
                           ||:.|:..|  ||..::.|........:|.:.
Mosquito   733 LKRYQTAIRADSEIYVPSDITLEN--LPEIESKGRHKTREGLLDPAVLIEGVLFRARYLGSTQLV 795

  Fly  1110 --GQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSS-----------------LRPLTSDDF 1155
              |||..:.|...:..       |.|.....:||:|||:                 |:.:..|
Mosquito   796 CEGQPTKSTRMMQAEE-------AVSRIKAPAGESQPSTEVDLFISTEKIMVLNTDLKEIMMD-- 851

  Fly  1156 QAMIPAHFLSGGSQHQVHVARPNEVGVS--------------------AVTVNVNKPQP--DLP- 1197
            .|:....:::...|..|.:||...|..|                    ||..:..|.:|  ..|
Mosquito   852 HALRTISYIADIGQLVVLMARRRFVASSTGPTDPAADDGGAVPGGPEAAVPADSPKKRPANRTPK 916

  Fly  1198 --------------------MFPAAPTELGRVTETITKSTFTETVMTRITDNQ---------LAE 1233
                                .|..|..|..:.......|...|.....:.::|         .|:
Mosquito   917 MICHVFESEEAQFIAQSIGQAFQVAYMEFLKANGIEDHSFMKELDYQEVLNSQEIFGDELEIFAK 981

  Fly  1234 PLISEEVVLPKNQGS-LGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKV 1297
            ..:.:|||:||.:|. ||..|:..      .:|:..|.:.|:::...|.|::||:|.:||:|:.:
Mosquito   982 KELQKEVVVPKAKGEILGVVIVES------GWGSMLPTVVIANLASAGAAARCGQLNIGDQIIAI 1040

  Fly  1298 NE---ADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGE-RLGMHIKGGLNGQ 1358
            |.   ..:..:|.| ..::..|....:|.|:.  |..| ..||.:.:...: :||..::.|:
Mosquito  1041 NGLSLVGLPLSTCQ-GYIKNTKNQTVVKFTVV--PCAP-VVEVKIKRPNTKYQLGFSVQNGV--- 1098

  Fly  1359 RGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEI 1420
                         :..:...|.|.|.| ::||.|::|:|..|::...|:..||:|..:..||
Mosquito  1099 -------------ICSLLRGGIAERGG-VRVGHRIIEINNQSVVAVPHEKIVNLLATSIGEI 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	16/106 (15%)
		PDZ_signaling	931..1016	CDD:238492	19/92 (21%)
		PDZ	1239..1329	CDD:214570	26/93 (28%)
		PDZ_signaling	1336..1425	CDD:238492	21/86 (24%)
AgaP_AGAP000452	XP_310641.4	PTB_X11	775..953	CDD:269919	28/186 (15%)
		PDZ_signaling	986..1071	CDD:238492	26/91 (29%)
		PDZ_signaling	1076..1149	CDD:238492	21/88 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910