DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and Lrrc39

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001366558.1	Gene:	Lrrc39 / 109245	MGIID:	1924557	Length:	355	Species:	Mus musculus

Alignment Length:	401	Identity:	99/401 - (24%)
Similarity:	167/401 - (41%)	Gaps:	118/401 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RQVEFVDK------RHCSLPQVPEEILRY-SRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDN 70
            |:.||..|      ...||.::.|::.|. .|.:  |.::....:.||.:..:|::|::..|...
Mouse    31 REKEFQHKLVRIWEDRVSLTKLKEKVTREDGRVI--LRIEKEEWKTLPSSLLKLNQLQEWQLHRT 93

  Fly    71 EIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLG 135
            .:.::|..|..|::|:.||:|||.|.:||..|
Mouse    94 GLLKIPEFIGRFQHLIVLDLSRNTISEIPRGI--------------------------------- 125

  Fly   136 LNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDN-EIEDLPPYLGYLPG 199
                         |.||:|:.|.|..|.:|.:|:.:|..|.|::|:|..| :|.|
Mouse   126 -------------GLLTRLQELILSYNKIKTVPKELSNCTSLEKLELAVNRDISD---------- 167

  Fly   200 LHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIA 264
                         |||||..|.|||:||:|.|:...:|:.:..:.:|..||:..|.|:.|||.:.
Mouse   168 -------------LPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSLD 219

  Fly   265 KLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLP 329
            ::..|..|.|.:|.:..|.:|:.|.:|:..|:|:.|.|.::|..:.:||
Mouse   220 RMRSLHTLWLQRNEITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMT---------------- 268

  Fly   330 LEIGQCANLGVLSLRDNKLK---KLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSEN 391
                   ||..::.|||.|:   .|||.         .:..|.:    ...|..||....::.|:
Mouse   269 -------NLRFVNFRDNPLRLEVTLPPS---------DNTDGEE----EQELFGLQFMHAYIQES 313

  Fly   392 QSQPLLTFQPD 402
            :...:...|||
Mouse   314 RRTGMRFEQPD 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	71/277 (26%)
		leucine-rich repeat	18..38	CDD:275380	5/26 (19%)
		LRR_8	37..95	CDD:290566	16/57 (28%)
		leucine-rich repeat	39..61	CDD:275380	4/21 (19%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR_8	84..138	CDD:290566	10/53 (19%)
		leucine-rich repeat	85..107	CDD:275380	10/21 (48%)
		leucine-rich repeat	108..130	CDD:275380	0/21 (0%)
		LRR_8	129..187	CDD:290566	15/58 (26%)
		leucine-rich repeat	131..153	CDD:275380	2/21 (10%)
		leucine-rich repeat	154..176	CDD:275380	7/21 (33%)
		leucine-rich repeat	177..199	CDD:275380	6/22 (27%)
		LRR_8	198..256	CDD:290566	18/57 (32%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	15/57 (26%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	0/21 (0%)
		LRR_4	337..375	CDD:289563	10/40 (25%)
		leucine-rich repeat	361..382	CDD:275380	2/20 (10%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrrc39	NP_001366558.1	LRR	19..>286	CDD:227223	88/348 (25%)
		LRR 1	84..105		4/20 (20%)
		leucine-rich repeat	85..107	CDD:275380	5/21 (24%)
		LRR 2	107..128		11/66 (17%)
		leucine-rich repeat	108..127	CDD:275380	10/64 (16%)
		LRR 3	130..152		7/21 (33%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		LRR 4	153..176		11/45 (24%)
		leucine-rich repeat	154..177	CDD:275380	12/45 (27%)
		LRR 5	177..198		8/20 (40%)
		leucine-rich repeat	178..200	CDD:275380	7/21 (33%)
		LRR 6	200..221		8/20 (40%)
		leucine-rich repeat	201..223	CDD:275380	8/21 (38%)
		LRR 7	223..244		6/20 (30%)
		leucine-rich repeat	224..246	CDD:275380	7/21 (33%)
		LRR 8	246..267		6/20 (30%)
		leucine-rich repeat	247..269	CDD:275380	7/44 (16%)
		LRR 9	269..290		9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910