DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and Scrib

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_598850.1 Gene:Scrib / 105782 MGIID:2145950 Length:1665 Species:Mus musculus


Alignment Length:2246 Identity:739/2246 - (32%)
Similarity:1017/2246 - (45%) Gaps:681/2246 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFKCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKL 65
            |.||||::: |||.||.||||||||..|||||.||||:||||.||||.:|:|||.||||..||||
Mouse     1 MLKCIPLWR-CNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64

  Fly    66 GLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKN 130
            |||||||.||||::.||..||||||||||||:||:.||..::|::||||.||:.:||.||:||::
Mouse    65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129

  Fly   131 LTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            |..|.|||:||..||.|.|:|..|.:|||||||||.||.::|.|.||::||||.|::|.||..||
Mouse   130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
            .||.|.|||||.|||..||||||.|.:|..||||||||||||.|:.||..||||.|:||||:.||
Mouse   195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLP 259

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
            :||.:|.:|:|||:|||||..:.:.:|:|||:.|||||||.|:.||.|:|::|||.|||||||.|
Mouse   260 EGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHL 324

  Fly   326 EYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSE 390
            |.||.|||.|..|.|||||||:|..|||||.:...||||||:||:|..||::|.:|.|||:||:|
Mouse   325 EVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHLNLKALWLAE 389

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSR-TVVKF---- 450
            ||:||:|.||.:.||:|||:||:|||||||....:..|....|.||...:...|| :|::|    
Mouse   390 NQAQPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDAGQQSSPSESCSDAPLSRVSVIQFEDTL 454

  Fly   451 -----SEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTE 510
                 :|||..||. ...|:.||||.:|  |..|..:|..|||.   .|..|:.:          
Mouse   455 EGEEDAEEAAAEKR-GLQRRATPHPSEL--KVMKRGIEERRNEA---FVCKPDPS---------- 503

  Fly   511 TRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAA 575
                      .|.|.::                  .....|.:.:.|||..::|||:..:...  
Mouse   504 ----------PPSPSEE------------------EKRLSAESALSGGSVPSASTASEGEPEI-- 538

  Fly   576 VVAELAATVGG---------SDEVQDDDEQED--EFESD----RRVGFQVEGEDDDFYKRP---P 622
                |.|.|.|         .:|..:||..|.  .|..|    |..|...||:.:..:..|   .
Mouse   539 ----LPAEVQGLGQHEAMPAQEEYTEDDYNEPTVHFAEDTLIPREDGESEEGQPEAAWPLPSGRQ 599

  Fly   623 KLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQE 687
            :|.|:||||:.|:.::..|...:|...|...:.:.....|...|:......:|...||:.|.|:|
Mouse   600 RLIRKDTPHYKKHFKISKLPQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEEEEEE 664

  Fly   688 QQQQQQ----QHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYE--IHIERTAAGLGLSIA 746
            .:.:::    ....|...:..||......|.|..|...:...|:|:.|  :.|.|...|||:|||
Mouse   665 NRDEEEGEATTEEDDKEEAVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIA 729

  Fly   747 GGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLV 811
            |||||||:||||:|||||||:|.|||..||::||||:::|||:.:.||:|::||:.|:..||.:.
Mouse   730 GGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQ 794

  Fly   812 LVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQ 876
            :.|.||  |:: .|         :.:|...||                                 
Mouse   795 MRVWRE--RMV-EP---------ENAVTITPL--------------------------------- 814

  Fly   877 QQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTT-LIRDQIGQG 940
             :|....:| ..:.|.....|    .:||              |.|:|..|.|.. |:|.:  :|
Mouse   815 -RPEDDYSP-REWRGGGLRLP----LLQP--------------ETPVSLRQRHAACLVRSE--KG 857

  Fly   941 LGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLT 1005
            |||||||||||.|::....|||||||.|||.|:|.|.:.|||||::|||.|||||.||.||:.||
Mouse   858 LGFSIAGGKGSTPYRAGDGGIFISRIAEGGAAHRAGTLQVGDRVLSINGVDMTEARHDHAVSLLT 922

  Fly  1006 EPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATT 1070
            .....:.|:|:||..|...|...|.|                                       
Mouse   923 AASPTISLLLERETGGTYPPSPPPHS--------------------------------------- 948

  Fly  1071 TPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTT 1135
            :|||..||.|::|                                    .:||            
Mouse   949 SPTPAATVAATVS------------------------------------TAVP------------ 965

  Fly  1136 SGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFP 1200
                ||                                                       |:.|
Mouse   966 ----GE-------------------------------------------------------PLLP 971

  Fly  1201 AAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFG 1265
                   |::.::..:.             |..|...||:.||:..|.||.||:||:|||..|||
Mouse   972 -------RLSPSLLATA-------------LEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFG 1016

  Fly  1266 TREPGIFISHIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPL 1330
            .::||:|||.::|.|:|::|| ||:|||||.||..||.:||||:||..||:|..|:.|.::.||.
Mouse  1017 VQDPGVFISKVLPRGLAARCG-LRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPP 1080

  Fly  1331 PPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLE 1395
            |||.:|:.:.||.||:||:.|:||..|..|||.||:|||:|:||::..|||.|||||:||:||||
Mouse  1081 PPGMRELCIQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLE 1145

  Fly  1396 VNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQG 1460
            ||..||||.:|.:||.:||:.|:.:.::||.|:|.|..     .|..:|.|..::...:|...:.
Mouse  1146 VNQQSLLGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTT-----TALEVSPGVIANPFAAGLGHRN 1205

  Fly  1461 SRASETGSELSQSQSVSSLDHE--------EDERLRQDFDVFASQ----KPDAQQPTGPSV---- 1509
            |           .:|:||:|.|        |.|        .|||    :.::.:.||.::    
Mouse  1206 S-----------LESISSIDRELSPEGPGKEKE--------LASQALPWESESAETTGRNLEPLK 1251

  Fly  1510 --LAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTV--ALIHAEQQAHQQQ 1570
              ..|.||:....|....|:||:           ......||.:|.:|..  .:|....||..:.
Mouse  1252 LDYRALAALPSAGSLQRGPSATT-----------GGKTTEAPCSPGSQQTKPGVIQPLAQAWPRN 1305

  Fly  1571 QQTQLAPLGQ-----EKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDT 1630
            ..   ||.|:     ..|..|....:.:|..||..||...|.|:                     
Mouse  1306 SP---APRGRGGPCSPPSPDELPANVKQAYRAFAAVPTVHPPEN--------------------- 1346

  Fly  1631 NPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQL 1695
            :.|.|.||.                     ||::|                           .||
Mouse  1347 SATQPPTPG---------------------PAASP---------------------------EQL 1363

  Fly  1696 QSTPASRDGAEEQQEEVRAKPTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEK 1760
                                        |..:::::||  :|.:....:...|..|.:..|::.|
Mouse  1364 ----------------------------SFRERQKYFE--LEVRVPQAEGPPKRVSLVGADDLRK 1398

  Fly  1761 LRQEEERKIATLRRDKNSRLLDAANDNIDKDAAQQRTKSNSNSSSGDDNDDSDQEEGIARGDSVD 1825
            :::||.||:    :.|.:::|                                :||.:..|    
Mouse  1399 MQEEEARKL----QQKRAQML--------------------------------REEAVTSG---- 1423

  Fly  1826 NAALGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLLPKPKVKV 1890
                      .||    .|||                                            
Mouse  1424 ----------PDM----GLAS-------------------------------------------- 1430

  Fly  1891 VIPPALQQRLKQQQVQQQQQQHQQSQPEEP-SIPEEEYHQQPEPDSPSAAGGSRIPVRTLKAERR 1954
                            .::....|.:.|:| ::|  .:.....|.||...||: .||||.|||||
Mouse  1431 ----------------DRESPDDQQEAEQPWAVP--SHAGGSSPSSPPPLGGN-APVRTAKAERR 1476

  Fly  1955 ALTLAARQSGLSVEEYLKRLETQDDKESPASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVE 2019
                           :.:||..| ..|.||.....:...|..:.|||||.|||||::||||.|:.
Mouse  1477 ---------------HQERLRMQ-SPELPAPERALSPAERRALEAEKRALWRAARMKSLEQDALR 1525

  Fly  2020 AQDVIKNMRKMTDDLITHESRASEVETCKERIISLELQVP-----ETEDEG-------------- 2065
            ||.|:..         :.|.|......  ||:.......|     ..||.|              
Mouse  1526 AQMVLSK---------SQEGRGKRGPL--ERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLPLSG 1579

  Fly  2066 ---------KLDDTQPPLELEADDFQDD----EDDDDDDDDEDDFEDEDEEEDTASIVTVQANNE 2117
                     .|..::|..::::.||.::    |........|:|.|        .::|       
Mouse  1580 KKFDYRAFAALPSSRPVYDIQSPDFVEELRTLEASPSPGSQEEDGE--------VALV------- 1629

  Fly  2118 KLFLRHDSDTYGP------SSIESVASGKVRIKPTP 2147
             |..|......||      ||..||..|:..:.|.|
Mouse  1630 -LLGRPSPGAVGPEDMTLCSSRRSVRPGRRGLGPVP 1664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 177/269 (66%)
leucine-rich repeat 18..38 CDD:275380 16/19 (84%)
LRR_8 37..95 CDD:290566 43/57 (75%)
leucine-rich repeat 39..61 CDD:275380 16/21 (76%)
leucine-rich repeat 62..84 CDD:275380 17/21 (81%)
LRR_8 84..138 CDD:290566 32/53 (60%)
leucine-rich repeat 85..107 CDD:275380 16/21 (76%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
LRR_8 129..187 CDD:290566 33/57 (58%)
leucine-rich repeat 131..153 CDD:275380 12/21 (57%)
leucine-rich repeat 154..176 CDD:275380 14/21 (67%)
leucine-rich repeat 177..199 CDD:275380 12/21 (57%)
LRR_8 198..256 CDD:290566 40/57 (70%)
leucine-rich repeat 200..222 CDD:275380 16/21 (76%)
leucine-rich repeat 223..245 CDD:275380 16/21 (76%)
LRR_8 267..325 CDD:290566 35/57 (61%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 12/21 (57%)
leucine-rich repeat 315..337 CDD:275380 16/21 (76%)
LRR_4 337..375 CDD:289563 23/37 (62%)
leucine-rich repeat 361..382 CDD:275380 12/20 (60%)
PDZ 728..816 CDD:214570 50/89 (56%)
PDZ_signaling 931..1016 CDD:238492 48/85 (56%)
PDZ 1239..1329 CDD:214570 48/89 (54%)
PDZ_signaling 1336..1425 CDD:238492 48/88 (55%)
ScribNP_598850.1 LRR_RI 12..232 CDD:238064 145/219 (66%)
leucine-rich repeat 14..37 CDD:275380 18/22 (82%)
leucine-rich repeat 38..60 CDD:275380 16/21 (76%)
LRR 39..405 CDD:227223 231/365 (63%)
leucine-rich repeat 61..83 CDD:275380 17/21 (81%)
leucine-rich repeat 84..106 CDD:275380 16/21 (76%)
leucine-rich repeat 107..129 CDD:275380 13/21 (62%)
leucine-rich repeat 130..152 CDD:275380 12/21 (57%)
leucine-rich repeat 153..175 CDD:275380 14/21 (67%)
leucine-rich repeat 176..198 CDD:275380 12/21 (57%)
leucine-rich repeat 199..221 CDD:275380 16/21 (76%)
leucine-rich repeat 268..290 CDD:275380 11/21 (52%)
LRR_4 289..329 CDD:289563 27/39 (69%)
leucine-rich repeat 291..313 CDD:275380 12/21 (57%)
leucine-rich repeat 314..336 CDD:275380 16/21 (76%)
leucine-rich repeat 360..381 CDD:275380 12/20 (60%)
PDZ 711..799 CDD:214570 49/87 (56%)
PDZ_signaling 854..933 CDD:238492 46/80 (58%)
PDZ_signaling 988..1076 CDD:238492 49/88 (56%)
PDZ_signaling 1085..1175 CDD:238492 48/89 (54%)
AbLIM_anchor 1565..>1659 CDD:292800 19/109 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2116
eggNOG 1 0.900 - - E33208_3BA7S
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 774 1.000 Inparanoid score I530
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48681
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 1 1.000 - - FOG0005473
OrthoInspector 1 1.000 - - otm44212
orthoMCL 1 0.900 - - OOG6_102427
Panther 1 1.100 - - LDO PTHR23119
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5064
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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