DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and si:ch73-281f12.4

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001272317.2	Gene:	si:ch73-281f12.4 / 102216267	ZFINID:	ZDB-GENE-130530-682	Length:	1144	Species:	Danio rerio

Alignment Length:	854	Identity:	165/854 - (19%)
Similarity:	282/854 - (33%)	Gaps:	293/854 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RLHRLRKLGL----SDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPI 118
            |..|.:|:..    ||..:..|...::..:.::|..||..|                   :....
Zfish   475 RRRRTQKIAARWRDSDGRVVSLSYQMEQEDRVLEKIVSMVD-------------------AGGED 520

  Fly   119 PKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLL---KHLPETISQLTK-LKR 179
            |||.:.|     |..|.:..           |.|..|.|.||..||   .|:...:.:.|| |..
Zfish   521 PKLTAAF-----LLCLCIQQ-----------SATDFELLHLRRLLLSIANHIQLDMWERTKELAA 569

  Fly   180 LDLGDNEIEDL--PPYLG---YLPGLHE--LWLDHN--QLQRLPPELGLLTKLTYLDVSENRLEE 235
            |....|.|:..  .|.|.   .:|||..  ||:.::  .|..:..|:.||  ||:.  .::|.|:
Zfish   570 LHPDTNSIDGTAEQPVLNMKELIPGLQPLVLWMSNSIELLHFIQHEVPLL--LTWR--QQDRQEQ 630

  Fly   236 LPNEISGLVSLTDL--DLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTL-----GNCENMQ 293
            ....:.|.:..|..  :.|..:||.:           |:...|..:..|...|     |
Zfish   631 DKEWLDGQIQCTRAASEEAMTVLEEV-----------IMFTFQQCVYYLTKILYAVLSG------ 678

  Fly   294 ELILTENFLSE-----LPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPP 353
              :|..|..||     :||.:.|:     |:|.:.||..|
Zfish   679 --LLDSNPFSESGQLRMPAGVSQI-----LDVLKEALHLL------------------------- 711

  Fly   354 ELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYL-- 416
               |...:| .:::...|.|| :...|..|....:..........:...........:|..::
Zfish   712 ---NTFQVH-REITSQLLTYL-FFFTNASLFNTLMERGSGGGFYQWSRGVQIRANLDLLMDWIQS 771

  Fly   417 -----LPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQN---------- 466
                 |..:.:|.::.|.:|.:        .|..|:::.|....:.:   ||..|
Zfish   772 IGLGDLAAEFFQKLSSAVNLLA--------TPKETLLQASWSTLRAE---FVHLNPAQLHHMLRE 825

  Fly   467 -----------TPHPKDLKAKAQKLKVERSRNEEHANLVTLPE-----ENGTKLAE----TPTE- 510
                       ||.|:|..|......:..| .:.|..|: ||.     |.|..:||    ||.:
Zfish   826 YNTSRTCPPCWTPSPEDAAAALHTSNILES-FDNHPPLI-LPSNIFHLELGKPIAEPGLFTPLQR 888

  Fly   511 ----TRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKA 571
                .:|:::...|..|            ||             ||          .|::|..:.
Zfish   889 LQEFIQTLSDCQTQPDH------------QP-------------AP----------DSSSNLTEE 918

  Fly   572 ATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNK 636
            :|:..|.           :|:.:.......|                :.||:.
Zfish   919 STSKSVT-----------IQNHESNHQHHVS----------------RTPPQF------------ 944

  Fly   637 RVQHLTDKQASEILANALASQERNDTTPQHSLSGK----------------VTSPIEEE--EQLE 683
            |..|........:|...|.|.|.     |:.|||.                :|.|...:  :|.|
Zfish   945 RASHNNLSSCEAVLTQKLKSLEL-----QNCLSGNADLVFHKSLALDPSCLLTPPNTPQNLDQAE 1004

  Fly   684 VEQE-----QQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGL 743
            :|..     ||..:|.|..::.||..:|.:..|...|.|          |.:.:.:::...||||
Zfish  1005 LEASLQDGGQQSIRQHHRVENGLSENTAQRKDEDEDDRD----------EVFTVELKKGPHGLGL 1059

  Fly   744 SIAGGKGSTPFKGDDDGIFISRVTEAGP-ADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACG 807
            ::..|: .|..:  .:|:::..|....| |....|:.||:::.|||:.:|..|::...::::..|
Zfish  1060 ALVDGQ-KTALR--VNGVYVKSVVPDSPAAQSQSLRTGDRILAVNGVSLVGMDYHSGRELIRTSG 1121

  Fly   808 AVLVLVVQR 816
            ..|.|:|.:
Zfish  1122 DSLRLLVAK 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	53/243 (22%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	9/40 (23%)
		leucine-rich repeat	39..61	CDD:275380	1/2 (50%)
		leucine-rich repeat	62..84	CDD:275380	4/25 (16%)
		LRR_8	84..138	CDD:290566	10/53 (19%)
		leucine-rich repeat	85..107	CDD:275380	4/21 (19%)
		leucine-rich repeat	108..130	CDD:275380	4/21 (19%)
		LRR_8	129..187	CDD:290566	16/61 (26%)
		leucine-rich repeat	131..153	CDD:275380	3/21 (14%)
		leucine-rich repeat	154..176	CDD:275380	7/24 (29%)
		leucine-rich repeat	177..199	CDD:275380	6/26 (23%)
		LRR_8	198..256	CDD:290566	16/63 (25%)
		leucine-rich repeat	200..222	CDD:275380	7/25 (28%)
		leucine-rich repeat	223..245	CDD:275380	5/21 (24%)
		LRR_8	267..325	CDD:290566	14/67 (21%)
		leucine-rich repeat	269..289	CDD:275380	5/24 (21%)
		leucine-rich repeat	292..314	CDD:275380	7/26 (27%)
		leucine-rich repeat	315..337	CDD:275380	5/21 (24%)
		LRR_4	337..375	CDD:289563	4/37 (11%)
		leucine-rich repeat	361..382	CDD:275380	5/20 (25%)
		PDZ	728..816	CDD:214570	23/88 (26%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
si:ch73-281f12.4	NP_001272317.2	RA	115..214	CDD:307093
		FHA	329..441	CDD:238017
		Myo5p-like_CBD_Rasip1	501..865	CDD:271256	88/469 (19%)
		PDZ_signaling	1045..1129	CDD:238492	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910