DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and lrrc18a

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_005157018.2	Gene:	lrrc18a / 101885955	ZFINID:	ZDB-GENE-090313-323	Length:	281	Species:	Danio rerio

Alignment Length:	166	Identity:	62/166 - (37%)
Similarity:	87/166 - (52%)	Gaps:	8/166 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLK 178
            :.|.:...|.|  :|:    |.|:::.:.|.|.....|..:|.|:|..|.||.:||.|.|.|.|:
Zfish    20 AKNALRATPEG--KLR----LDLSNVGIATFPKCLLKLRNVEELDLSRNKLKTIPEFIGQFTGLR 78

  Fly   179 RLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQR--LPPELGLLTKLTYLDVSENRLEELPNEIS 241
            .|||..|:||.||..:|.|..|..|.|.:|.|..  |.||:|.|..|..|::..|||..||..::
Zfish    79 WLDLHSNQIERLPENIGLLRSLVHLNLCNNNLDSAGLSPEIGSLRNLQVLNLGMNRLNALPPTLA 143

  Fly   242 GLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQN 277
            ||.:||:|.|..||...:|:....|..||.|...:|
Zfish   144 GLTNLTELGLFDNLFTQVPECTRVLPNLTKLNTKRN 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	62/166 (37%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	6/23 (26%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	4/15 (27%)
		LRR_8	129..187	CDD:290566	21/57 (37%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	11/21 (52%)
		LRR_8	198..256	CDD:290566	24/59 (41%)
		leucine-rich repeat	200..222	CDD:275380	10/23 (43%)
		leucine-rich repeat	223..245	CDD:275380	9/21 (43%)
		LRR_8	267..325	CDD:290566	4/11 (36%)
		leucine-rich repeat	269..289	CDD:275380	4/9 (44%)
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc18a	XP_005157018.2	leucine-rich repeat	34..53	CDD:275380	5/18 (28%)
		LRR_RI	<36..160	CDD:238064	51/123 (41%)
		LRR_8	52..110	CDD:290566	26/57 (46%)
		leucine-rich repeat	54..76	CDD:275380	10/21 (48%)
		leucine-rich repeat	77..99	CDD:275380	11/21 (52%)
		LRR_8	98..158	CDD:290566	24/59 (41%)
		leucine-rich repeat	100..124	CDD:275380	10/23 (43%)
		leucine-rich repeat	125..147	CDD:275380	9/21 (43%)
		leucine-rich repeat	148..170	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910