DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and LOC101730428

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_004919457.2	Gene:	LOC101730428 / 101730428	-ID:	-	Length:	970	Species:	Xenopus tropicalis

Alignment Length:	926	Identity:	189/926 - (20%)
Similarity:	326/926 - (35%)	Gaps:	253/926 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LQSLQVADFSS---------NPIPKL-PSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLEL 159
            |.|:.:||...         |.:..: .|.|..|..|..|.|::.::|....:|.  ..||.|.|
Frog    42 LTSVPIADIHKDTAILILKYNDLKSVTASTFKGLSLLLELDLSNNAMTNFKVEFA--LGLEELNL 104

  Fly   160 RENLLKHLPETISQLTKLKRLDLGDNEIEDLP-PYLGYLPGLHELWLDHNQLQRLPPEL-GLLTK 222
            ..|.|.|:| .:|.||.|.:|.|..|.|..:| ....:|..|.:|:|.||.:..|..:: ....:
Frog   105 ANNSLDHIP-NLSLLTNLNKLILSHNRITSVPDAAFHHLKNLQQLYLQHNGIHYLSEQVFEHSQQ 168

  Fly   223 LTYLDVSENRLEELPNE-ISGLVSLTDLDLAQNLLEALPDGIAK-LSRLTILKLDQNRLQ----- 280
            |..||:|.|:|..:|.. ||....|....|..|.|..:||...: |:.|..:.||.|..|
Frog   169 LHTLDLSYNKLVSVPRHLISHAEKLDKFYLTGNRLTEIPDDFFEGLANLAYVYLDDNPFQCNCAL 233

  Fly   281 -----RLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGV 340
                 .:.|...|...|::...|::..|.:..|..::..||           .|::  .|:|.|
Frog   234 ENFKAWVEDNSFNIYTMKDGDTTQDEYSVVCTSPNKVPLLN-----------FPMD--HCSNTG- 284

  Fly   341 LSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSENQSQPLLTFQPDTD 404
                ||.              :|.:..|..  |:.||:.:: .:.....:...|..:|.....||
Frog   285 ----DND--------------YVTNTVGTD--YVKYSVTSIHSILTTQKARLVSPTMLQTSTLTD 329

  Fly   405 AETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEA------TQEKETPFV 463
            |.|                      .::|::..||....:.|::...:.|      |.|.:|
Frog   330 APT----------------------TIKSETTEFEISSETPTILSTLDAAEAATTTTAEFQT--- 369

  Fly   464 RQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQ-- 526
            .:.|..||.:...:.:.::.   :|....|.||.....|..||..|.|:|.|      |..::
Frog   370 SKLTDAPKSITPGSTEFEIS---SETPMILSTLDAAEATTTAEFQTSTQTDA------PTTIKAG 425

  Fly   527 QPIVGVNSKQPVVVGVV--TPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAATVGGSDE 589
            .|...|:|:.|:::..:  ...|||         :|..:||..:..:|:.:..:.|..|
Frog   426 SPEFEVSSETPMILSTMDAAEATTT---------AEFQTSTQTSKTSASRSACSHLCTT------ 475

  Fly   590 VQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANAL 654
                         ::.|                          :|:|:....|....:.|....:
Frog   476 -------------EKNV--------------------------VKDKQETQCTHMGLTYIPLTCI 501

  Fly   655 ASQERNDTTPQHSLSGKVTSPIEEEEQLEVE-----------------QEQQQQQQQHPFDSSLS 702
            .|.........:.|:...||.:::...||::                 :|.............||
Frog   502 PSNTSILILKYNDLTSITTSTLKDLPLLELDLSNNAVTSFTADFPLGLEELNLANNSINHIPDLS 566

  Fly   703 PISAGKTAEASTD-----PD----NLDGVTELRLEQYEIH------IERTAAGLGLSIAGGK--G 750
            |::..||...|.:     ||    :|..:..|.|:...||      .||:.....|.::..|  |
Frog   567 PLTNLKTLILSHNYISCVPDTAFHDLKNLHHLYLQHNGIHYLSEQVFERSQQLQTLDLSNNKLIG 631

  Fly   751 ------STPFKGDDDGIFISRVTE------AGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVL 803
                  |...|.|...:..:|:.|      .|..:||.:.:.|...:.|    ..:::::....:
Frog   632 VPWHLISHAKKLDKFYLTGNRLMEIPDDFFEGLKNLAYVYLDDNPFRCN----CASENFKTWVEV 692

  Fly   804 KACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAP---PAASISHERYIPAPIEI 865
            .|.....:                 :||:.:|   :...:|..:|   |..:.|.:.....|.:.
Frog   693 NAFNIYTI-----------------KDGATTQ---DEYSVVCASPYKVPLLNFSMDHCSTEPSKP 737

  Fly   866 V-----PQQQHLQQQQQQPIQQV-APTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPL- 923
            :     |..|..|:.:.....|| .||...:.:...|||......|.|..:|   |:   :|||
Frog   738 ITTTPTPYVQPTQKARVLSTTQVRVPTTELTTSTQDTPTTRSPQTPTVPTSP---LV---DAPLP 796

  Fly   924 -------SYIQLHTTL 932
                   |.::|.||:
Frog   797 TTLASEPSTLKLSTTI 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	58/201 (29%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	11/42 (26%)
		leucine-rich repeat	85..107	CDD:275380	1/1 (100%)
		leucine-rich repeat	108..130	CDD:275380	6/31 (19%)
		LRR_8	129..187	CDD:290566	20/57 (35%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	7/22 (32%)
		LRR_8	198..256	CDD:290566	18/59 (31%)
		leucine-rich repeat	200..222	CDD:275380	6/22 (27%)
		leucine-rich repeat	223..245	CDD:275380	9/22 (41%)
		LRR_8	267..325	CDD:290566	13/67 (19%)
		leucine-rich repeat	269..289	CDD:275380	6/29 (21%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	4/21 (19%)
		LRR_4	337..375	CDD:289563	7/37 (19%)
		leucine-rich repeat	361..382	CDD:275380	5/21 (24%)
		PDZ	728..816	CDD:214570	18/107 (17%)
		PDZ_signaling	931..1016	CDD:238492	1/2 (50%)
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
LOC101730428	XP_004919457.2	leucine-rich repeat	56..77	CDD:275380	4/20 (20%)
		leucine-rich repeat	78..93	CDD:275380	4/14 (29%)
		PPP1R42	85..227	CDD:411060	46/144 (32%)
		leucine-rich repeat	99..120	CDD:275380	10/21 (48%)
		LRR_8	119..179	CDD:404697	19/59 (32%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		LRRCT	225..278	CDD:214507	11/63 (17%)
		PRK15370	<501..>677	CDD:185268	34/175 (19%)
		leucine-rich repeat	507..526	CDD:275380	3/18 (17%)
		leucine-rich repeat	528..543	CDD:275380	2/14 (14%)
		leucine-rich repeat	549..570	CDD:275380	4/20 (20%)
		leucine-rich repeat	571..594	CDD:275380	6/22 (27%)
		leucine-rich repeat	595..618	CDD:275380	6/22 (27%)
		leucine-rich repeat	619..642	CDD:275380	4/22 (18%)
		leucine-rich repeat	643..666	CDD:275380	4/22 (18%)
		TPKR_C2	675..728	CDD:417692	9/76 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910