DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and podn

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_031756818.1	Gene:	podn / 101730272	XenbaseID:	XB-GENE-963382	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	131/545 - (24%)
Similarity:	219/545 - (40%)	Gaps:	163/545 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 IRDLPKNF--FRLHRLRKLGLSDNEIGRLPP-DIQNFENLVELDVSRNDIPD--IPDDI-KHLQ- 106
            :|:.|.|.  ..:|    |.|.:|:|..:|| |:.....|..|::..|.:..  ||||: :||:
Frog    79 LREFPSNLPDIIIH----LSLQNNQIEEIPPEDLTRLYKLETLNLQNNRLTSRGIPDDLFEHLEK 139

  Fly   107 --------------------SLQVADFSSNPIPKL-PSGFSQLKNLTVLGLNDMSLTT--LPAD- 147
                                ||..|||::|.|.|: ...|....||..:.|:|..||.  :|.:
Frog   140 LNYLYLANNKLSLAPRFLPSSLISADFAANNITKIYEMTFGHKPNLRSVYLHDNKLTDAGIPDNM 204

  Fly   148 FGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPP-YLGYLPGLHELWLDHNQLQ 211
            |....::|:|.|..|.||::|:.:.  ..|.:|.|.:|::|.:|. ...:|..|.||:|.:|:|.
Frog   205 FNRSNRVETLILSSNFLKYVPKNLP--PALCKLHLQNNKLESIPSGAFSHLTDLRELYLLNNRLS 267

  Fly   212 RLPPELGL-------LTKLTYLDVSENRLEELPNEIS---------------------------- 241
                ..|:       |.||.|||:|.|.|.::|:.:.
Frog   268 ----NEGMDNETFTKLNKLEYLDLSSNNLTKIPSGLPRNIVILHLEKNSIRFISDNVLTQIRNLE 328

  Fly   242 --------------------GLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRL--ND 284
                                ||..|..:.:..||||.:|.|:.:  |:..|.|..|::..:  ||
Frog   329 YLLLHNNKLRAHGIHPGAFVGLKKLHTVHVYNNLLEKVPPGLPR--RVKTLMLLHNQISSISKND 391

  Fly   285 TLGNCENMQELILTENFLSELPASIGQMTK--------LNNLNVDRNALEYLPLEIGQCANLGVL 341
             ......:::|.|:.|.:..     |.:.|        |..|.:..|.|:.:|  .|...||.:|
Frog   392 -FATTYLLEDLNLSYNKIMS-----GNVHKEAFRKLRLLKTLELSGNNLKSVP--YGLPKNLEIL 448

  Fly   342 SLRDNKLKKLPPE------------LGN---------------CTVLHVLDVSGNQLLYLPYSLV 379
            .|:||.:..:|.:            |.|               .:.|.:||:|||||.|:|..|.
Frog   449 RLKDNDISSIPQDSLTGMIKLKEFYLSNNKLKLSSFYSGAWAELSSLQILDLSGNQLSYIPSDLP 513

  Fly   380 NLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEE---- 440
            . .|:.::|   ||..::|.. |:..|:...:...:|    .:..:|.....|...|..|:
Frog   514 E-TLEYLYL---QSNKIITVD-DSAFESTPNIKGIFL----RFNLLTAGSVKEGAFEGLEKLQVL 569

  Fly   441 ------REPSRTVVKFSEEATQEKE 459
                  .:.||...|.::::.:|:|
Frog   570 DIENNLTKASRKKEKDTKQSEEEEE 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	81/322 (25%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	14/48 (29%)
		leucine-rich repeat	39..61	CDD:275380	3/13 (23%)
		leucine-rich repeat	62..84	CDD:275380	7/22 (32%)
		LRR_8	84..138	CDD:290566	21/78 (27%)
		leucine-rich repeat	85..107	CDD:275380	9/45 (20%)
		leucine-rich repeat	108..130	CDD:275380	8/22 (36%)
		LRR_8	129..187	CDD:290566	19/60 (32%)
		leucine-rich repeat	131..153	CDD:275380	7/24 (29%)
		leucine-rich repeat	154..176	CDD:275380	7/21 (33%)
		leucine-rich repeat	177..199	CDD:275380	7/22 (32%)
		LRR_8	198..256	CDD:290566	21/112 (19%)
		leucine-rich repeat	200..222	CDD:275380	8/28 (29%)
		leucine-rich repeat	223..245	CDD:275380	10/69 (14%)
		LRR_8	267..325	CDD:290566	14/67 (21%)
		leucine-rich repeat	269..289	CDD:275380	5/21 (24%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	6/21 (29%)
		LRR_4	337..375	CDD:289563	18/64 (28%)
		leucine-rich repeat	361..382	CDD:275380	11/20 (55%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
podn	XP_031756818.1	LRRNT	59..87	CDD:396168	3/7 (43%)
		leucine-rich repeat	90..113	CDD:275380	8/26 (31%)
		PLN00113	105..>512	CDD:215061	104/422 (25%)
		leucine-rich repeat	114..139	CDD:275380	9/24 (38%)
		leucine-rich repeat	140..184	CDD:275380	9/43 (21%)
		leucine-rich repeat	185..210	CDD:275380	7/24 (29%)
		leucine-rich repeat	211..231	CDD:275380	7/21 (33%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		leucine-rich repeat	256..281	CDD:275380	8/28 (29%)
		leucine-rich repeat	282..302	CDD:275380	8/19 (42%)
		leucine-rich repeat	303..326	CDD:275380	0/22 (0%)
		leucine-rich repeat	327..352	CDD:275380	2/24 (8%)
		leucine-rich repeat	353..373	CDD:275380	7/21 (33%)
		leucine-rich repeat	374..397	CDD:275380	5/23 (22%)
		leucine-rich repeat	398..423	CDD:275380	5/29 (17%)
		leucine-rich repeat	424..445	CDD:275380	6/22 (27%)
		leucine-rich repeat	446..468	CDD:275380	5/21 (24%)
		leucine-rich repeat	469..494	CDD:275380	2/24 (8%)
		leucine-rich repeat	495..515	CDD:275380	11/20 (55%)
		LRR_8	515..575	CDD:404697	12/67 (18%)
		leucine-rich repeat	516..539	CDD:275380	7/26 (27%)
		leucine-rich repeat	540..565	CDD:275380	4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910