DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Pdzd7

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001182194.1	Gene:	Pdzd7 / 100503041	MGIID:	3608325	Length:	1021	Species:	Mus musculus

Alignment Length:	1314	Identity:	273/1314 - (20%)
Similarity:	427/1314 - (32%)	Gaps:	498/1314 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 SPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAG-LGLSIAGGK--GSTPFKGDDDGIFI 763
            |||      ||::|..::         .:.:.:|::.:| ||.|:.||.  |.        |||:
Mouse    72 SPI------EANSDESDI---------IHAVRVEKSPSGRLGFSVRGGSEHGL--------GIFV 113

  Fly   764 SRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFS 828
            |:|.|...|:.|||.||||:.:|||:.:.......||::|.:...:.::|  |.:.|:.|.. ||
Mouse   114 SKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVRLLTSSSCLHMMV--RRMGRVPGIK-FS 175

  Fly   829 EDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNV 893
            :: ..:.:.|..|.||                                   :::.:.|
Mouse   176 KE-KTTWVDVVNRRLV-----------------------------------VEKCSST------- 197

  Fly   894 FATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGK--GSPPFKD 956
                       |:..::.:|:        ...:.|:||  .|..  .|||:|.|||  |.
Mouse   198 -----------PSDRSSEDGV--------RRIVHLYTT--SDDF--CLGFNIRGGKEFGL----- 234

  Fly   957 DCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRG 1021
               ||::|::..||||..:| |.|||:|:|.||....:..|..||..| :.|..:.|.::...|.
Mouse   235 ---GIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVL-KGQTHIMLTIKETGRY 294

  Fly  1022 PLEPPTSPR-------SPAVLNSLSP--------SGYLANRPANFSRSV----VEV----EQPYK 1063
            |........       |..||..|||        |.|.::.|.: |.|:    ::|    |:|..
Mouse   295 PAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSSYASSAPCS-SGSLPSDRMDVCLGPEEPTS 358

  Fly  1064 Y-------NTLATTTP----------TPKPTV-----------PASISNNNNTLPSSKTNGFATA 1100
            :       :|...|.|          :.:|||           |:|..:.::.|..|.......|
Mouse   359 HGPGWGRADTAMQTEPDLDSRVETWCSVRPTVILRDTAIRSDGPSSTRHLDSALSESPKTALLLA 423

  Fly  1101 AAATIDSSTGQP-VPAPRRTNSVPMGDGDIGAGSTTSGDSGE----AQPSSLRPLTSDDFQAMIP 1160
            .:        :| .|..|..:.:.:.:.........||.|||    .:..:|..|
Mouse   424 LS--------RPRTPITRSQSHLTLWEEKKQRKKEKSGSSGEKGALQRSKTLMNL---------- 470

  Fly  1161 AHFLSGGSQHQVHVARPNEVG-VSAVTVNVNKP---QPDLPMFPAAPTELGRVTETITKSTFTET 1221
              |..||.|     .||...| ..|.|::...|   :|.|.:..|.  .:|.|.:.:|
Mouse   471 --FFKGGRQ-----GRPAGDGHREAWTLDSRSPTKVRPRLDLEKAG--SVGPVQKFVT------- 519

  Fly  1222 VMTRI-TDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKC 1285
              .|: .|.:....|:|.....|..|...       .:.....:.:|.|          .|....
Mouse   520 --WRLRRDRERGRALLSARSGSPSGQAPT-------VNEQVQAWESRRP----------LIQDLA 565

  Fly  1286 GKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMH 1350
            .:|...|.:|.|.. ..|:..|:..|.:|::|    .|.|...|     .::||
Mouse   566 RRLLTDDEVLAVTR-HCSRYVHEGGVEDLVRP----LLAILDRP-----TKLLL----------- 609

  Fly  1351 IKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLE-----VNGHSLLGASHQDAV 1410
                |...|...| |:|.|.|.|.:           :.|.:...|     ..|.|.|..:.||..
Mouse   610 ----LRDIRSVVA-PTDLGRFDSMV-----------MPVELEAFEALKSRAVGPSALRPTRQDTP 658

  Fly  1411 NVLRNAGNEIQLVVCKGYDKSNLIHSIGQAGGMSTGF-----NSSASCSGGSRQGSRASETGSEL 1470
                              .|.:||..:..:.|   ||     |||....|..|      |....|
Mouse   659 ------------------PKRHLITPVPDSRG---GFYLLPVNSSEDEDGEIR------EKLGVL 696

  Fly  1471 SQSQSVSSLDHEEDERLRQD--FDVFASQKPDAQQPTGPSVLAAAAAMVHGASSPTPPAATSNIT 1533
            ..|...|:..|:....| ||  .|.|:.::.....|..|..:|           |.||.....:|
Mouse   697 KVSLGASAPHHKGIPPL-QDVPVDAFSLRRGACAPPPQPPPVA-----------PRPPRPNWLLT 749

  Fly  1534 -PLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADA 1597
             ||                          :.:...|.|.||......:.:|
Mouse   750 EPL--------------------------SREDTQQNQSQTPAQSCSRSRS-------------- 774

  Fly  1598 FTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPA 1662
                  :|.|..|.:.:                                .:|.....:|||| |.
Mouse   775 ------RSRSRSHSRGQ--------------------------------GKSPGRRRSPSPA-PI 800

  Fly  1663 STPGSA-----------PVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKP 1716
            :|..:|           |:||.: :..|.......:...|..::         |||....|....
Mouse   801 ATAATANGRYHRPRKARPLLPRL-LDGQVAKVGARQGPLENGRI---------AEEAVGNVSTGA 855

  Fly  1717 ----TPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVF----SFLSKD----------EVEKLRQ 1763
                |.:|:.:|:...   ....:|.:.:|..|.:|:|    :||..|          :.|.|.|
Mouse   856 LRTITLSKMKQSLGIS---ISGGIESKVQPMVKIEKIFPGGAAFLCGDLQAGFELVAVDGESLEQ 917

  Fly  1764 -EEERKIATLRRDKNSR---------------LLDAAND-NIDKDAAQQRTKSNSNSSSGDDNDD 1811
             ..:|.:.|:||...::               ||..|:| .:.||           .|...|..
Mouse   918 VTHQRAVDTIRRAYRNKAREPMELVVRVPGPGLLPLASDLRVVKD-----------QSLAPDCP- 970

  Fly  1812 SDQEEGIARGDSVDNAALGHFDDA---------EDMRTAQSLASTMPHAPSKIPKQKLKAKQIES 1867
                           :|||..|||         |..:..|||:|.: ..|..|||.
Mouse   971 ---------------SALGPVDDARILTQLPPPEARQLQQSLSSAL-KVPQSIPKL--------- 1010

  Fly  1868 SLPTPTALDPPKPS 1881
               :|...||..||
Mouse  1011 ---SPILKDPHDPS 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	29/90 (32%)
		PDZ_signaling	931..1016	CDD:238492	32/86 (37%)
		PDZ	1239..1329	CDD:214570	16/89 (18%)
		PDZ_signaling	1336..1425	CDD:238492	17/93 (18%)
Pdzd7	NP_001182194.1	PDZ_signaling	84..164	CDD:238492	29/89 (33%)
		PDZ_signaling	209..289	CDD:238492	34/93 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..345		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..495		17/80 (21%)
		HN_PDZD7_like	554..631	CDD:259824	25/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..814		25/179 (14%)
		PDZ_signaling	856..944	CDD:238492	18/90 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	992..1021		11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910