DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and apba3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_002941438.2	Gene:	apba3 / 100495034	XenbaseID:	XB-GENE-995533	Length:	630	Species:	Xenopus tropicalis

Alignment Length:	716	Identity:	143/716 - (19%)
Similarity:	242/716 - (33%)	Gaps:	248/716 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   845 ADAPPAASISHERYIPAPIEI-VPQQQ---------HLQQQQQQPIQQVAPTHSYSGNVFATPTA 899
            |.:||.:|.......|:.|:: .|||.         |..|..:.|: .:.||......|.:.|.
Frog     5 AQSPPVSSCHMRTQTPSQIDMETPQQYEECSVSCSLHSSQSLEDPV-CMDPTDRAPPRVDSCPD- 67

  Fly   900 AQTVQPAVSAAPNGLLLNGREAPLSYIQLH------TTL-----IRDQI---------------G 938
             ...:|.::...|.:.|:| :.|.....:.      |||     :|..:               |
Frog    68 -MDTRPPLTPELNVMDLDG-DVPGEGFHMQELLNELTTLEEPLDVRPSLNNLNEATDNLEGQAEG 130

  Fly   939 QGLGFSIAGGKG----------SPPFKDDCDGIFISRITEGG-------LAYRDGKIM-VGDRVM 985
            |.....||.|||          |.....:..|:|   :|:.|       ..:.:|.:. ||..|.
Frog   131 QPCPLHIAMGKGLSEKPRRVSESETMLSNSRGLF---LTDAGSEELLHLFQHEEGVLADVGSAVP 192

  Fly   986 AINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLAN--RP 1048
            .....::.:  :.::|:|          .||...:|..|.         :...|||.:.::  |.
Frog   193 LARLEELPK--NKSSVSC----------SLQEAGKGSSEE---------VKQKSPSSFSSDLCRE 236

  Fly  1049 ANFSRSVVEVEQPYKYNTLATTT---PTPKPTVPASISN---------NNNTLPSSKTNGFAT-- 1099
            .:|| |:.||......:|.:.||   ..|.|..|..:.:         .:..||..|....:|
Frog   237 DSFS-SLEEVPDEETLDTPSETTSAAKVPGPCDPEDLKDGVIFGAQYLGSTQLPGEKHPVASTRM 300

  Fly  1100 -AAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGS----TTSGDSGEA----------------- 1142
             .|...:|.     :.|| ...|.||.:.||...:    ..|.||.|:
Frog   301 RQAQEAVDR-----IKAP-DGESQPMTEVDIMVSTRRVKVLSADSQESLMDHPLHTISFTADIGS 359

  Fly  1143 ----------------QPSSLRP-------LTSDDFQAMIPA----------HFL---------S 1165
                            .|:..:|       ..|||.|.:..|          .||         |
Frog   360 IVVLMARRKIPRTQDQSPTQRKPNRILCHVFQSDDAQLIAQAIGQAFGLAYQKFLCSDRVGPLTS 424

  Fly  1166 GGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQ 1230
            |..|.:.|:.                 ..|||.|..:.:
Frog   425 GSGQREEHLY-----------------NADLPHFSKSDS-------------------------- 446

  Fly  1231 LAEPLISEEVVLPKNQGS-LGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRI 1294
                  ..||.:.|.:|. ||.:::..      .:|:..|.:.|::::.||.|.:.|.|.:||.:
Frog   447 ------CREVYIQKQRGEMLGIAVVES------GWGSLLPTVVIANLMHGGPAERSGDLSIGDHV 499

  Fly  1295 LKVNEAD---VSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLN 1356
            ..||...   :..:|.|..:.: ||...|:.|:|..  .||....::...:...:||..:
Frog   500 TSVNGTSLVGLPFSTCQGLIRD-LKGQSEVILSIVR--CPPVITAIIQRPSVSHQLGFCV----- 556

  Fly  1357 GQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQ 1421
                      ::||..|.:.. |.|.|.| ::||.|::|:||.|::..:|:..:..|.:|..|:.
Frog   557 ----------EDGVICSLVRG-GIAERGG-IRVGHRIIEINGQSVVATAHEKIIQTLMDATGEVH 609

  Fly  1422 L 1422
            :
Frog   610 I 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	21/122 (17%)
		PDZ	1239..1329	CDD:214570	25/93 (27%)
		PDZ_signaling	1336..1425	CDD:238492	20/87 (23%)
apba3	XP_002941438.2	PTB_X11	269..414	CDD:269919	25/150 (17%)
		PDZ_signaling	448..525	CDD:238492	22/83 (27%)
		PDZ_signaling	538..611	CDD:238492	20/90 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910