DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc18

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_002939784.1	Gene:	lrrc18 / 100493348	XenbaseID:	XB-GENE-993703	Length:	257	Species:	Xenopus tropicalis

Alignment Length:	218	Identity:	70/218 - (32%)
Similarity:	99/218 - (45%)	Gaps:	32/218 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 RKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQ 127
            |:|.||...|..||..:....::.|||:|||.|..:||.|:..|:|:..|..||.|.|||....|
Frog    30 RRLDLSKMGIAALPKCLLKLCDVEELDLSRNLIRKVPDWIQRFQNLRWLDLHSNQIEKLPESIGQ 94

  Fly   128 LKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPP 192
            |:.|..|.:::..:|.                     |.:|..::||..|:.|:||.|.|:.||.
Frog    95 LQGLLHLNVSNNKITA---------------------KGIPLELNQLKNLRLLNLGLNTIDMLPT 138

  Fly   193 YLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRL----EELP-------NEISGLVSL 246
            .||.|..|.|:.|..|||..||..:..|.||..|:...|.:    |||.       ..:..|..:
Frog   139 TLGALKELKEVGLFDNQLTSLPTSIIKLPKLKKLNTRRNPIPPTQEELHETEKDTIQRVEALYLV 203

  Fly   247 TDLDLAQNLLEALPDGIAKLSRL 269
            ...||.|..|....:...||::|
Frog   204 DQKDLCQPCLSKCQEERNKLNKL 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	70/218 (32%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	13/31 (42%)
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380	7/20 (35%)
		LRR_8	84..138	CDD:290566	23/53 (43%)
		leucine-rich repeat	85..107	CDD:275380	10/21 (48%)
		leucine-rich repeat	108..130	CDD:275380	10/21 (48%)
		LRR_8	129..187	CDD:290566	12/57 (21%)
		leucine-rich repeat	131..153	CDD:275380	3/21 (14%)
		leucine-rich repeat	154..176	CDD:275380	4/21 (19%)
		leucine-rich repeat	177..199	CDD:275380	11/21 (52%)
		LRR_8	198..256	CDD:290566	20/68 (29%)
		leucine-rich repeat	200..222	CDD:275380	9/21 (43%)
		leucine-rich repeat	223..245	CDD:275380	7/32 (22%)
		LRR_8	267..325	CDD:290566	1/3 (33%)
		leucine-rich repeat	269..289	CDD:275380	1/1 (100%)
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc18	XP_002939784.1	leucine-rich repeat	30..51	CDD:275380	7/20 (35%)
		PRK15370	<52..>234	CDD:185268	63/196 (32%)
		leucine-rich repeat	52..74	CDD:275380	10/21 (48%)
		leucine-rich repeat	75..97	CDD:275380	10/21 (48%)
		leucine-rich repeat	98..145	CDD:275380	18/67 (27%)
		leucine-rich repeat	146..168	CDD:275380	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910