DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc32.1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_004912272.1	Gene:	lrrc32.1 / 100489763	XenbaseID:	XB-GENE-994459	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	136/504 - (26%)
Similarity:	213/504 - (42%)	Gaps:	131/504 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VEFVDKRHCSLPQVPEE-ILRYSRTLEELFLDANHIRDL-PKNFFRLHRLRKLGLSDNE------ 71
            ::.:|..|..|..:.|: :::|| .||.|.|.:|.:..: |.:|.::|:|:::.||.|:
Frog    52 IQTLDLSHNDLENITEDHLMKYS-FLESLDLSSNQLSFIQPHSFRKMHKLKEINLSGNDLDSFVH 115

  Fly    72 -----IGRLP-------------PD-----IQNFENLVELDVSRNDIPDIPDDI-KHLQSLQVAD 112
                 ||.||             .|     :|....|..|.:..|.|..|..|: :....|...|
Frog   116 HRVSGIGVLPYVQTLDLSRNSLYNDMIGYFLQEAPRLQYLSLHENSITTISSDLFQGSPLLAEVD 180

  Fly   113 FSSNPIPKLPSG-FSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLK--HLPET---- 170
            ..:|.|..:..| |..||:|:::.|:..|:|.: :|| :|.||:.|.|.:|.:|  |.|::
Frog   181 LHNNIIMDIEEGSFEYLKHLSMIDLSMNSITCI-SDF-NLRQLKVLNLSKNSIKTFHTPDSEDEY 243

  Fly   171 -----------ISQLTKLKR------LDLGDNEI--------EDLPPYLGY-------------- 196
                       :|...:|.|      :||..|.|        || |.::.|
Frog   244 LLEKVDLSHNKLSSFPQLPRVNNVIFIDLSKNYIHLGTETPGED-PDWMNYSFQLEFEEQNPKNI 307

  Fly   197 ----LPGLHELWLDHNQLQRLPPELGL-LTKLTYLDVSENRLEELP-NEISGLVSLTDLDLAQNL 255
                ||.|:.|.|.:|.::.:|.:..| :..||:|::|:|.::.|. ...|||.||..|||:.|.
Frog   308 STVPLPKLNHLDLSYNSIKSIPDDFFLTMPSLTFLNLSKNCIQVLSLGHFSGLSSLATLDLSANS 372

  Fly   256 LEALPDGIAKLSRLTILKLDQNRL--------QRLNDT----------------LG--------- 287
            ::.|..|...|..|..|.|..|:|        |||...                ||
Frog   373 IQNLSLGANSLPSLQRLYLQHNQLRLLEPRIFQRLESIVLLHLQGNHVGPCMAGLGKAKRRTHAE 437

  Fly   288 --------NCENMQELILTENFLSELPASIGQMTKLNNLNVDRN-ALEYLPLEI-GQCANLGVLS 342
                    |...:|.|.|.||.:..:|||....|.|..|::..| .::..|..: |....|.||.
Frog   438 EYRCVEFFNIPTLQHLNLRENMIQRIPASAFWGTSLKVLDLSMNLGIKVKPNALFGLEKTLEVLF 502

  Fly   343 LRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSEN 391
            :..|.|..|..:|...|.|..|::|||||..||....:.:|:.:.||.|
Frog   503 MEGNGLPSLNVDLPLFTHLKYLNLSGNQLSELPEWNSDCRLETLDLSLN 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	97/359 (27%)
		leucine-rich repeat	18..38	CDD:275380	6/20 (30%)
		LRR_8	37..95	CDD:290566	21/87 (24%)
		leucine-rich repeat	39..61	CDD:275380	7/22 (32%)
		leucine-rich repeat	62..84	CDD:275380	10/50 (20%)
		LRR_8	84..138	CDD:290566	16/55 (29%)
		leucine-rich repeat	85..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..130	CDD:275380	7/22 (32%)
		LRR_8	129..187	CDD:290566	22/80 (28%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	8/38 (21%)
		leucine-rich repeat	177..199	CDD:275380	11/53 (21%)
		LRR_8	198..256	CDD:290566	22/59 (37%)
		leucine-rich repeat	200..222	CDD:275380	6/22 (27%)
		leucine-rich repeat	223..245	CDD:275380	9/22 (41%)
		LRR_8	267..325	CDD:290566	23/99 (23%)
		leucine-rich repeat	269..289	CDD:275380	10/60 (17%)
		leucine-rich repeat	292..314	CDD:275380	8/21 (38%)
		leucine-rich repeat	315..337	CDD:275380	5/23 (22%)
		LRR_4	337..375	CDD:289563	15/37 (41%)
		leucine-rich repeat	361..382	CDD:275380	9/20 (45%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc32.1	XP_004912272.1	LRR_8	50..110	CDD:404697	18/58 (31%)
		leucine-rich repeat	52..75	CDD:275380	6/23 (26%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		PLN00113	99..>579	CDD:215061	122/456 (27%)
		leucine-rich repeat	100..151	CDD:275380	10/50 (20%)
		leucine-rich repeat	152..175	CDD:275380	6/22 (27%)
		leucine-rich repeat	176..199	CDD:275380	7/22 (32%)
		leucine-rich repeat	200..220	CDD:275380	7/21 (33%)
		leucine-rich repeat	245..314	CDD:275380	12/69 (17%)
		leucine-rich repeat	315..338	CDD:275380	6/22 (27%)
		leucine-rich repeat	339..362	CDD:275380	9/22 (41%)
		leucine-rich repeat	363..385	CDD:275380	8/21 (38%)
		leucine-rich repeat	386..409	CDD:275380	8/22 (36%)
		leucine-rich repeat	410..449	CDD:275380	3/38 (8%)
		leucine-rich repeat	450..472	CDD:275380	8/21 (38%)
		leucine-rich repeat	473..520	CDD:275380	12/46 (26%)
		leucine-rich repeat	498..512	CDD:275378	5/13 (38%)
		leucine-rich repeat	521..542	CDD:275380	9/20 (45%)
		leucine-rich repeat	543..566	CDD:275380	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910