Protein Alignment scrib and htra4

DIOPT Version :9

• Sequence 1: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Sequence 2: XP_017211746.2
• Gene: htra4 / 100334257
• ZFINID: ZDB-GENE-131120-192
• Length: 459
• Species: Danio rerio
• Alignment Length: 387
• Identity: 77/387 - (19%)
• Similarity: 122/387 - (31%)
• Gaps: 146/387 - (37%)

  Fly  1020 RGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVP----- 1079
            |||.|  |..|:|:.:.                         ||:|.:|.......|.|.
Zfish   132 RGPCE--TGSRNPSSMR-------------------------YKFNFIADVVDKIAPAVVHLELF 169

  Fly  1080 ASISNNNNTLPSSKTNGFATA-----------------------------------------AAA 1103
            :.:..:|..:|.|..:||..:                                         |..
Zfish   170 SRLPFSNQDVPVSSGSGFIVSEDGWIVTNAHVLSNKQRIKVELKNGMLYDATIKDVDQKLDIALI 234

  Fly  1104 TIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTS----------------GDSGEAQPSSLRPLTS 1152
            .|||.|..||....|::.:..|:..:..||..|                |.....|.|.:..:.:
Zfish   235 KIDSETALPVLLLGRSSDLRPGEFVVAVGSPFSLQNTVTTGIISTTHRGGHELGLQNSDMEYIQT 299

  Fly  1153 DDFQAMI-------PAHFLSGGSQHQVHVARPNEVGVSAVTV----NVNKPQPDLPMFPAAPTEL 1206
            |   |:|       |...|.|           :.:|::.:.|    :...|...:..|.|...|.
Zfish   300 D---AIINYGNSGGPLVNLDG-----------DVIGINTLKVTPGISFAIPSDRIRQFLADSYER 350

  Fly  1207 GRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGI 1271
            .|...|:||..:....|.     ||:..||.|   |.:.:.|               |.....|:
Zfish   351 QRKGRTLTKKKYMGVRML-----QLSAALIRE---LREKESS---------------FPDVSSGV 392

  Fly  1272 FISHIVPGGIASKCGKLRMGDRILKVN------EADVSKATHQDAVLELL--KPGDEIKLTI 1325
            ::..::||..|...|.|.. |.|:.:|      ..|||:|...:.:|.|:  :...||.||:
Zfish   393 YVYEVIPGTAAFSAGMLNQ-DVIISINGQPVYSTEDVSQAVQSNEILSLMVRRAQKEITLTV 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	22/95 (23%)
		PDZ_signaling	1336..1425	CDD:238492
htra4	XP_017211746.2	IGFBP	27..80	CDD:306685
		KAZAL_FS	92..135	CDD:238052	2/2 (100%)
		DegQ	118..459	CDD:223343	77/387 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910