DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and magi3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_012811019.1	Gene:	magi3 / 100036692	XenbaseID:	XB-GENE-981179	Length:	1595	Species:	Xenopus tropicalis

Alignment Length:	1453	Identity:	281/1453 - (19%)
Similarity:	502/1453 - (34%)	Gaps:	402/1453 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   827 FSEDGSVSQISVETR------PLVADAPPAASISHERYIPAPIEIVPQQQ-------HLQQQQQ- 877
            ::|.|.:..|...|:      |.:.....|.....:..:|...|.:...|       |:.|:.|
Frog   299 YTEAGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHINQKTQF 363

  Fly   878 -QPI------QQVAPTHSYSGNVFATPTAAQ-TVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIR 934
             .|:      :|:.|..| .|.|...|..:| |..|               :.|....|||:|.:
Frog   364 DNPVLEAKRKKQLNPAPS-EGTVHQEPENSQFTRDP---------------SQLKGALLHTSLKK 412

  Fly   935 DQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDA 999
            .  ..|.||:|.||.....|      :.:..:.:.|.|.:||||..||.::.|||..:....|..
Frog   413 S--AMGFGFTIIGGDRPDEF------LQVKNVLKDGPAAQDGKIAPGDVIVDINGTCVLGHTHAE 469

  Fly  1000 AVAC--LTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSP--------SGYLANRPANFSRS 1054
            .|..  |....::|.:.|.|.|  ||...:......::|::.|        .|.:..........
Frog   470 VVQMFQLIPINQYVNMTLCRGY--PLPEDSDDPVADIVNTVPPIINGQMLTQGDINMGSQELKSG 532

  Fly  1055 VVEVEQPYKYNTLATTTPTPKPTVP-----ASISNNNNTLPSSKT-------NGFATAAAATIDS 1107
            |::::|..|...:........|::.     .|::::.|:||...|       .||..|.|   ||
Frog   533 VIDLDQRGKPGLMVVNGRLNGPSLDIQDQRTSMASSGNSLPELVTIPLLKGPKGFGFAIA---DS 594

  Fly  1108 STGQPVPAPRRTNSVP-MGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQ 1171
            ..||.|.....:...| :..||:.................:..|......|.:|...|.||....
Frog   595 PMGQKVKMILDSQWCPGLQKGDVIKEICHQNVQNLTHIQVVEVLKQFPVGAEVPLLILRGGPPSP 659

  Fly  1172 VHVAR----PNEV--GVSAVTVNVNKPQPDLPMFP---------AAPTELGRVTETI--TKSTFT 1219
            ..|.:    ..|:  .:.|:......||| ||..|         ..|:|:.:.::.|  .|...|
Frog   660 SKVTKVKSDKQELMGSIEAIAPGEPLPQP-LPFPPNLARSCSPKLDPSEVYKKSKNIFEDKPPNT 723

  Fly  1220 ETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASK 1284
            :.:                :|.|.|.:...||.::||..        .:..|:|..|:|.|.|.|
Frog   724 KDL----------------DVFLRKQESGFGFRVLGGDG--------PDQAIYIGAIIPLGAAEK 764

  Fly  1285 CGKLRMGDRILKVNEADVSKATHQDAVLELL---------------------KPGDEIKLTIQHD 1328
            .|:||..|.::.::...|...:|:. ||:|:                     |..:|.:|  ||.
Frog   765 DGRLRAADELICIDGVPVKGKSHKQ-VLDLMTNAARNGHVLLTVRRQIYYTDKQQEEEEL--QHT 826

  Fly  1329 P-------------------LPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSK 1374
            |                   ||....:|:|.:.:.|..|..|   |..:...|     .||...|
Frog   827 PPAHNGSPRLNRIEVSAIPKLPAEAYDVILQRKDNEGFGFVI---LTSKNKPP-----PGVIPHK 883

  Fly  1375 INSV---GAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNLIHS 1436
            |..|   ..|.|..:||||.|:..|||.|::..||.:.|.::::|||.:.|.|....:..
Frog   884 IGRVIEGSPADRCRKLKVGDRISAVNGQSIVELSHDNIVQLIKDAGNTVTLTVIAEEEHR----- 943

  Fly  1437 IGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDA 1501
                 |..:|.||:.  ...:.|.....:|..........|..||:.|
Frog   944 -----GPPSGSNSAR--QSPAPQHRPMGQTQPTYGTLDRYSWSDHKAD----------------- 984

  Fly  1502 QQPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLT----------------APD 1550
               .||::.|.:.           .|.:....|:...........:                |.|
Frog   985 ---CGPALPAGSW-----------QAQSVGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAED 1035

  Fly  1551 TPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADA--------FTTVPPKSPS 1607
            .||.:...:...:|......:.||       ..|..:.:|:::|..:        .|.:.|
Frog  1036 GPAIKDGRIHVGDQIVEINNEPTQ-------GITHTRAIELIQAGGSKVLLLLRPGTGLIP---- 1089

  Fly  1608 EHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLP 1672
            :::|.|....::|.|:.:.....:.|:.|||     :.|.....:.......||     ...::|
Frog  1090 DYNELDSAHPSSTSVVFEDLTTFSSTSFTTP-----VPGVSCLKNYDEGFVEVP-----EKDIVP 1144

  Fly  1673 AVAVQTQTQTTS----TEKDEEEESQLQSTPAS--------RDGAEEQQEEV------RAKPTPT 1719
            ...:|.....||    :.:|:|.||..|..|.|        :|.:...:..:      .||....
Frog  1145 KDNIQKSRNVTSLPSFSTQDQEMESFQQDNPVSDFLNNSKTKDASVSPRNTISMNQLEAAKENGK 1209

  Fly  1720 KVPKSVSDKKRFFESAME-----DQHKPTQKTDKVFSFLSKDEVEKLRQEEERKI---------- 1769
            :..:|||.||...:::..     .:|:         .::||:..:  |....||:
Frog  1210 RRGRSVSPKKSINKNSSSHLDGLQEHR---------EYVSKEIRD--RSTSPRKVHTKTTEGVAD 1263

  Fly  1770 -ATLRRDK--------NSRLLDAANDNIDKDAA-QQRTKSNSN-SSSGDDNDD-----SDQEEGI 1818
             .||..|:        .|......|:.:.|::. :|:::|.|: ||:..:|.|     .|:.|..
Frog  1264 KVTLSNDQTRGYRGRSTSPKKPYKNEGVAKESTREQKSQSRSHRSSTKPENQDQVREIKDKHEKS 1328

  Fly  1819 ARGDSVDNAALGHFDDAEDMRTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPTALDPPKPSLL 1883
            .|||..:.    ..:|.:..|:.:...:.......:|.|.|::.:
Frog  1329 KRGDRGEK----QNNDEKHERSGKEERNEKTKKEERIEKNKMEER-------------------- 1369

  Fly  1884 PKPKVKVVIPPALQQRLKQQQVQQQQQQHQQSQPEEPSIPEEEYHQ------QPEPDSPSAAGG- 1941
                         .::.|:::...::::.:.::..:.::.|::.::      :.|.|:.|...|
Frog  1370 -------------SEKNKREERSDKKKEEKVAKSSKEAVDEKKVNEKYDKCMKEERDAKSRKEGT 1421

  Fly  1942 ------------SRIPVRTLKAERRALTLAARQSGLSVEEYLK-------RLETQDDKES--PAS 1985
                        |:...|..|:.|......:|:...:|.:|.|       :|:|.:.|::  .:|
Frog  1422 EDKSKRGQRLDKSKRDERAEKSRREERDEKSRRDEKNVIQYEKKTDEKTEKLKTSNSKDTDEKSS 1486

  Fly  1986 PTTPTGKSRSMINAEKRASWRAARLRSLEQGAVEAQDVIKNMRKMTDDLITHESRASEVETCKER 2050
            |...:.|.......:|..|.|..:....|..           :|.|..:|....:.:|:..|::.
Frog  1487 PQQKSKKEEKTTVLQKSVSDREQKRHETEPS-----------KKQTQGIIQKSGKEAEMAQCRDS 1540

  Fly  2051 IIS--------LELQVPETEDEG 2065
            |:|        ......:|:|||
Frog  1541 IVSHNEPHKKTTAENTEKTKDEG 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	23/86 (27%)
		PDZ	1239..1329	CDD:214570	28/110 (25%)
		PDZ_signaling	1336..1425	CDD:238492	30/91 (33%)
magi3	XP_012811019.1	PDZ_signaling	31..97	CDD:238492
		NK	119..>193	CDD:388413
		WW	290..322	CDD:197736	5/22 (23%)
		WW	337..368	CDD:197736	7/30 (23%)
		PDZ	410..490	CDD:214570	24/87 (28%)
		PDZ	574..655	CDD:214570	17/83 (20%)
		PDZ_signaling	727..808	CDD:238492	23/89 (26%)
		PDZ_signaling	852..937	CDD:238492	30/92 (33%)
		PDZ_signaling	1004..1082	CDD:238492	10/84 (12%)
		PTZ00121	<1202..1571	CDD:173412	71/421 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910