DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC3 and HDAC9

DIOPT Version :10

Sequence 1:NP_651978.2 Gene:HDAC3 / 44446 FlyBaseID:FBgn0025825 Length:438 Species:Drosophila melanogaster
Sequence 2:NP_848512.1 Gene:HDAC9 / 9734 HGNCID:14065 Length:1069 Species:Homo sapiens


Alignment Length:446 Identity:114/446 - (25%)
Similarity:181/446 - (40%) Gaps:101/446 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYT 87
            ||....|:....|.:...||..|.:..:..|||.:::...|| |:.:.|....|.:.|       
Human   657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQ------- 713

  Fly    88 KYLAHFSVGEDCPVF-------------DGLFD------FCAMYTGASLEGAQKLNHNHSDICIN 133
            |......:|:|...|             |.:::      ...|..|..:|.|.|:.         
Human   714 KLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVA--------- 769

  Fly   134 WSGGL-----------HHAKKFEASGFCYVNDIVIGILELLKY------HPRVLYIDIDVHHGDG 181
             ||.|           |||::..|.|||:.|.:.|    ..||      ..::|.:|:|||||:|
Human   770 -SGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAI----TAKYLRDQLNISKILIVDLDVHHGNG 829

  Fly   182 VQEAFYLTDRVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNVPLKEGID----DQSYFQV 240
            .|:|||....::..|.|:|  || ||||:|...|:|...|..|::|:....|:|    |..|.:.
Human   830 TQQAFYADPSILYISLHRYDEGN-FFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEA 893

  Fly   241 FKPIISAIMDFYRPTAIVLQCGADSLAGDR--LGCFSLSTKGHGECVKFVKELNVPTLVVG-GGG 302
            |:.|:..:...:.|..:::..|.|:|.|..  ||.:.::.|..|...|.:..|....:|:. .||
Human   894 FRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG 958

  Fly   303 YTLRNVARCWTHE--TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVK 365
            :.|  .|.|...|  .:.|:..::|   |..|             :|..:..|.|:...|:.|::
Human   959 HDL--TAICDASEACVNALLGNELE---PLAE-------------DILHQSPNMNAVISLQKIIE 1005

  Fly   366 HVYENLKMCQHSPSVQMVQTPPDVDL--EELRSNREEAS-----DPDVRISVADED 414
                  ...::..||:||..|....|  .:|:...|..|     ..||....|.||
Human  1006 ------IQSKYWKSVRMVAVPRGCALAGAQLQEETETVSALASLTVDVEQPFAQED 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC3NP_651978.2 HDAC3 4..388 CDD:212529 105/411 (26%)
HDAC9NP_848512.1 Interaction with CTBP1. /evidence=ECO:0000250 23..27
ClassIIa_HDAC9_Gln-rich-N 38..127 CDD:197399
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..142
Interaction with MEF2. /evidence=ECO:0000250 139..157
Interaction with MAPK10. /evidence=ECO:0000250 178..346
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..252
Interaction with ETV6. /evidence=ECO:0000269|PubMed:12590135 221..264
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..307
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..539
HDAC_classIIa 634..1011 CDD:212544 100/400 (25%)
Histone deacetylase 634..981 92/348 (26%)
Blue background indicates that the domain is not in the aligned region.

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