Protein Alignment HDAC3 and HDAC3

DIOPT Version :9

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_001341968.1
• Gene: HDAC3 / 8841
• HGNCID: 4854
• Length: 434
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 273/404 - (67%)
• Similarity: 343/404 - (84%)
• Gaps: 8/404 - (1%)

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            :.|:|||:.|||||||||||||||.|||:|||||::|||:|||.:::||:||..||.||||::||
Human     3 KTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYI 67

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            .:||:|:|.|:|    .:||.|..|:||:|||||.|||:||:.||||||:||.:||:...||.||
Human    68 DFLQRVSPTNMQ----GFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAIN 128

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            |:||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||.|||
Human   129 WAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFH 193

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            |||||||||||||||:||||||||.:||||::|||||||..:|:|:|:.::|||:||.|||||||
Human   194 KYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGA 258

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||..||||||:||.:||||||::||..|:|.||:||||||:||||||||:||||||::.|..:|
Human   259 DSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEEL 323

  Fly   329 PATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDLEE 393
            |.:||:::|||||||||::::|.:|.||:|||:.|.:.::|||||..|:||||:...|.|:
Human   324 PYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADL---- 384

  Fly   394 LRSNREEASDPDVR 407
            |..:|.:.:|.:.|
Human   385 LTYDRTDEADAEER 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	268/383 (70%)
HDAC3	NP_001341968.1	HDAC3	3..383	CDD:212529	267/379 (70%)
		Histone deacetylase	3..316		230/312 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	482	1.000	Domainoid score	I410
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48250
Inparanoid	1	1.050	616	1.000	Inparanoid score	I901
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62154
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	1	1.000	-	-		oto89044
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9795
SonicParanoid	1	1.000	-	-		X4957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.900