DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and HDA1

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_014377.1	Gene:	HDA1 / 855710	SGDID:	S000004966	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	499	Identity:	109/499 - (21%)
Similarity:	206/499 - (41%)	Gaps:	111/499 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGL-------------HKKMKIYRPYK- 53
            |.|:.|........|.|...||..|:|:...:.::...||             ...:||  |.:
Yeast    63 DVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKI--PVRA 125

  Fly    54 ASAQDMLRFHSDEYIAYLQQVTP-------------QNIQCNSVAYTKYLAHFSVGEDCPVFDGL 105
            |:::::|..|:.|::.:::....             .::..|:.:|..  |....|       |.
Yeast   126 ATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYAS--ARLPCG-------GA 181

  Fly   106 FDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHP--- 167
            .:.|.    |.:||..|     :.:.:....| |||:...|.|||..:::.:....:||.:|
Yeast   182 IEACK----AVVEGRVK-----NSLAVVRPPG-HHAEPQAAGGFCLFSNVAVAAKNILKNYPESV 236

  Fly   168 -RVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKY--GNYFFPGT--GDMYEIGAESGRYYSVNV- 226
             |::.:|.|:|||:|.|::||..|:|:..|.|::  |.| :|||  |...:.|...|..::.|:
Yeast   237 RRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKY-YPGTIQGQYDQTGEGKGEGFNCNIT 300

  Fly   227 -PLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKE 290
             |: .|:.|..|...|:.::..:...::|..:::..|.|:..||.:|...::...:|.....:|.
Yeast   301 WPV-GGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKS 364

  Fly   291 LNVPTL-VVGGGGYTLRNVARCWTHETSLLVDQDIENDLP--------------------ATEYY 334
            |....| ||..|||.|..:||.......:|:.:. .::||                    .::|:
Yeast   365 LARGNLCVVLEGGYNLDAIARSALSVAKVLIGEP-PDELPDPLSDPKPEVIEMIDKVIRLQSKYW 428

  Fly   335 DFF--------------------APDFTLHPEINSRQDNANSKQY----LELIVKHVYENLKMCQ 375
            :.|                    :.:|.|...|..:|.:..|.::    |.|:...:.:|..:|
Yeast   429 NCFRRRHANSGCNFNEPINDSIISKNFPLQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLC- 492

  Fly   376 HSPSVQMVQTPPDV--DLEELRSNREEASDP-DVRISVADEDKL 416
             :|::....|...|  |..::.:.|...|.. |:..||..::.|
Yeast   493 -TPNISESNTIIIVVHDTSDIWAKRNVISGTIDLSSSVIIDNSL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	100/465 (22%)
HDA1	NP_014377.1	HDAC_Clr3	81..403	CDD:212542	81/345 (23%)
HDA1	NP_014377.1	Arb2	457..698	CDD:401634	18/81 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810