Protein Alignment HDAC3 and RPD3

DIOPT Version :9

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_014069.1
• Gene: RPD3 / 855386
• SGDID: S000005274
• Length: 433
• Species: Saccharomyces cerevisiae
• Alignment Length: 424
• Identity: 235/424 - (55%)
• Similarity: 318/424 - (75%)
• Gaps: 12/424 - (2%)

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            |||:|||:|||||:.|||||||||.|:.:.|||:|||||:|||:|||...|:.|:|.:||:||||
Yeast    19 RRVAYFYDADVGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYI 83

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            .:|.:|||.|::    .:.:....|:||:||||||||:::|::..|.|:|||.:||....|:.:|
Yeast    84 DFLSRVTPDNLE----MFKRESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAVN 144

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            ::||||||||.|||||||:||||:||:|||:||||||||||||||||||:||||.||||||.|||
Yeast   145 YAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFH 209

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            |||. ||||||::.:||..:|:.|:|||||::||||.:|..||:|:|..||::|:|:|:|||||.
Yeast   210 KYGE-FFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQCGG 273

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||:|||||||:||.:||..||.:||...:|.:||||||||:|||||.|..||.||.:..::.||
Yeast   274 DSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDKDL 338

  Fly   329 PATEYYDFFAPDFTL--HPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDV-D 390
            |..|||:::.||:.|  .|   |...|.|:.:||:.::.:::.||:..:::||||:..||.|. |
Yeast   339 PYNEYYEYYGPDYKLSVRP---SNMFNVNTPEYLDKVMTNIFANLENTKYAPSVQLNHTPRDAED 400

  Fly   391 LEELRSNREEASDPDVRISVADEDKLVDAKNEFY 424
            |.::..:..||.|.......| .|..|:..||||
Yeast   401 LGDVEEDSAEAKDTKGGSQYA-RDLHVEHDNEFY 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	222/385 (58%)
RPD3	NP_014069.1	RPD3-like	18..392	CDD:212528	220/380 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344784
Domainoid	1	1.000	64	1.000	Domainoid score	I2431
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.600