DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC3 and Hdac5

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_038942911.1	Gene:	Hdac5 / 84580	RGDID:	619980	Length:	1120	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	106/434 - (24%)
Similarity:	172/434 - (39%)	Gaps:	93/434 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNI 79
            ||.|.   ||....|:....|.:...||..|.:..|..||:..::...|| ||...|...:|.|.
  Rat   709 GNTHV---HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNR 769

  Fly    80 QCNSVAYTKYLAHFSVGEDCPVFDGLFDF--CAMYTGASLEGAQKLNHNHSDICINWSGGL---- 138
            |  .:...|.|.        |:...::..  |.   |..::.....|..||...:..:.|.
  Rat   770 Q--KLDSKKLLG--------PISQKMYAMLPCG---GIGVDSDTVWNEMHSSSAVRMAVGCLVEL 821

  Fly   139 --------------------HHAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDVHHGD 180
                                |||::..|.|||:.|.:.| ..:||:..   .:||.:|.|:|||:
  Rat   822 AFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAI-TAKLLQQKLSVGKVLIVDWDIHHGN 885

  Fly   181 GVQEAFYLTDRVMTASFHKYGN-YFFPGTGDMYEIGAESGRYYSVNVPLKEGID----DQSYFQV 240
            |.|:|||....|:..|.|:|.| .||||:|...|:|...|..|:|||....|:|    |..|...
  Rat   886 GTQQAFYDDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTA 950

  Fly   241 FKPIISAIMDFYRPTAIVLQCGADSLAG--DRLGCFSLSTKGHGECVKFVKELNVPTLVVGG--- 300
            |:.::..|...:.|..:::..|.|::.|  ..||.:|::.:..|...:.:..|      .||
  Rat   951 FRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTL------AGGRVV 1009

  Fly   301 ----GGYTLRNVARCWTHE--TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQY 359
                ||:.|  .|.|...|  .|.|:..:::                .|...:..::.:.|:...
  Rat  1010 LALEGGHDL--TAICDASEACVSALLSVELQ----------------PLDEAVLQQKPSINAVAT 1056

  Fly   360 LELIVKHVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASD 403
            ||.:::      ...:|...||...|.....|.|.::..:|.::
  Rat  1057 LEKVIE------IQSKHWSCVQRFATGLGCSLREAQTGEKEEAE 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	103/417 (25%)
Hdac5	XP_038942911.1	ClassIIa_HDAC_Gln-rich-N	87..174	CDD:421006
Hdac5	XP_038942911.1	Arginase_HDAC	689..1105	CDD:418394	106/434 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810