Protein Alignment HDAC3 and Hdac1l

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_445898.1
• Gene: Hdac1l / 84576
• RGDID: 619975
• Length: 484
• Species: Rattus norvegicus
• Alignment Length: 432
• Identity: 245/432 - (56%)
• Similarity: 332/432 - (76%)
• Gaps: 14/432 - (3%)

  Fly     2 TDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDE 66
            |:|:|.|:|:.||||::||.||||||.|:.:||:|::||||::||:||||:||:|::|.::|||:
  Rat     7 TERKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    67 YIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDIC 131
            ||.:|:.:.|.|:.    .|:|.:..|:||||||||||||:||.:.||.|:..|.|||...:||.
  Rat    72 YIKFLRSIRPDNMS----EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIA 132

  Fly   132 INWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHH--GDGVQEAFYLTDRVMT 194
            :||:||||:|||.||||||||||||:.||||||||.||||||||:||  ||||:||||.||||||
  Rat   133 VNWAGGLHYAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGDGVEEAFYTTDRVMT 197

  Fly   195 ASFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVL 259
            .||||||.| ||||||:.:|||..|:||:||.||::||||:||..:|||::|.:|:.::|:|:||
  Rat   198 VSFHKYGEY-FPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVL 261

  Fly   260 QCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDI 324
            |||:|||:|||||||:|:.|||.:||:|||..|:|.|::||.|||:.|||||||:||::.:|.:|
  Rat   262 QCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGDGYTIHNVARCWTYETAVALDTEI 326

  Fly   325 ENDLPATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPP 387
            .|:||..:|:::|.|||.||  |   |...|.|:.:|||.|.:.::|||:|..|:|.|||...|.
  Rat   327 PNELPYNDYFEYFGPDFKLHISP---SNMTNQNTNEYLEKIKQRLFENLRMLPHTPGVQMQAIPE 388

  Fly   388 DVDLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429
            |...||  |..|:..|||..||:...||.:..:.||.|.|::
  Rat   389 DAIPEE--SGDEDEEDPDKPISICSSDKCIACEEEFPDSDEE 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	228/387 (59%)
Hdac1l	NP_445898.1	Arginase_HDAC	4..376	CDD:450134	223/376 (59%)