Protein Alignment HDAC3 and HDAC10

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_114408.3
• Gene: HDAC10 / 83933
• HGNCID: 18128
• Length: 669
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 80/319 - (25%)
• Similarity: 138/319 - (43%)
• Gaps: 49/319 - (15%)

  Fly    26 KPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYL---QQVTPQNIQCNSVAY- 86
            :|:||......:...||.::.......:||.:::...||.||::.:   |.:..:.:|..|..:
Human    27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFD 91

  Fly    87 -------TKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKF 144
                   |.:.|..:.|....:.|      |:.|||...|          :.:....| ||.::.
Human    92 AIYFHPSTFHCARLAAGAGLQLVD------AVLTGAVQNG----------LALVRPPG-HHGQRA 139

  Fly   145 EASGFCYVNDIVIGILELLKYH--PRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKY--GNYF- 204
            .|:|||..|::.|......:.|  .|:|.:|.|||||.|:|..|.....|:..|:|:|  |.::
Human   140 AANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204

  Fly   205 FPGTGDMYEIGAESGRYYSVNVPLKE-GIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAG 268
            |....|...:|...|..::||:|..: |:.:..|...|..::..:...:.|..:::..|.||..|
Human   205 FLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG 269

  Fly   269 DRLGCFSLSTKGHGECVKFVKELNVPTLVVGG-------GGYTLRNVAR--CWTHETSL 318
            |..|    ..:...||...:.:|  ..::.||       |||.|.::|.  |.|.:|.|
Human   270 DPEG----QMQATPECFAHLTQL--LQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLL 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	80/319 (25%)
HDAC10	NP_114408.3	Histone deacetylase	1..323		80/319 (25%)
		HDAC10	18..354	CDD:212546	80/319 (25%)
		Substrate specificity. /evidence=ECO:0000250|UniProtKB:F1QCV2	21..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..387
		Arginase_HDAC	<562..634	CDD:450134