DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and HD1

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_195526.1	Gene:	HD1 / 829969	AraportID:	AT4G38130	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	436	Identity:	238/436 - (54%)
Similarity:	321/436 - (73%)	Gaps:	16/436 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            |:|.|||:.:|||::||.||||||.|:.:||:|:.:|||.:.|::.:|:.|..:|:.|||:|:|:
plant    17 RKVCYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARDRDLCRFHADDYV 81

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            ::|:.:||:..|    ...:.|..|:|||||||||||:.||..|.|.|:.|:.||||...||.||
plant    82 SFLRSITPETQQ----DQIRQLKRFNVGEDCPVFDGLYSFCQTYAGGSVGGSVKLNHGLCDIAIN 142

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            |:||||||||.||||||||||||:.||||||.|.||||:|||:||||||:||||.||||||.|||
plant   143 WAGGLHHAKKCEASGFCYVNDIVLAILELLKQHERVLYVDIDIHHGDGVEEAFYATDRVMTVSFH 207

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            |:|:| |||||.:.:||..||:|||:||||.:||||:||..:||||:..:|:.:||.|:||||||
plant   208 KFGDY-FPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLLFKPIMGKVMEIFRPGAVVLQCGA 271

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||:|||||||:||.|||.|||||::..|||.|::||||||:|||||||.:||.:.:..::|:.:
plant   272 DSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGVEVEDKM 336

  Fly   329 PATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDL 391
            |..|||::|.||:|||  |   |..:|.||:|.||.|...:..||...||:|||...:.|||.:.
plant   337 PEHEYYEYFGPDYTLHVAP---SNMENKNSRQMLEEIRNDLLHNLSKLQHAPSVPFQERPPDTET 398

  Fly   392 EELRSNREEAS---DPDVRISVADEDKLVDA--KNEFYDGD-QDQD 431
            .|:..::|:..   |||..:.|.|:.|.:.:  |.|..:.| :|:|
plant   399 PEVDEDQEDGDKRWDPDSDMDVDDDRKPIPSRVKREAVEPDTKDKD 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	223/385 (58%)
HD1	NP_195526.1	Arginase_HDAC	17..395	CDD:418394	223/385 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710