Protein Alignment HDAC3 and HDAC11

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_079103.2
• Gene: HDAC11 / 79885
• HGNCID: 19086
• Length: 347
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 77/290 - (26%)
• Similarity: 113/290 - (38%)
• Gaps: 47/290 - (16%)

  Fly    37 VMNYGLHKKM----KIYRPYKASAQDMLRFHSDEY---------IAYLQQVTPQNIQCNSVAYTK 88
            |:|:...:|:    .:....:||.:|:|..|:..|         :|.:.::.|.....|.:...|
Human    45 VINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRK 109

  Fly    89 YLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVN 153
            .|.....                .||.::. |.||..... ..||..||.||.......|||...
Human   110 VLRPLRT----------------QTGGTIM-AGKLAVERG-WAINVGGGFHHCSSDRGGGFCAYA 156

  Fly   154 DIVIGI---LELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEIG 215
            ||.:.|   .|.::...|...||:|.|.|:|.:..|....||.....  |..:.:|  ||.:...
Human   157 DITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYP--GDRFAKQ 217

  Fly   216 AESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKG 280
            |...:     |.|:.|.:|..|....:..|...:..:.|..:|...|.|.|.|||||..|:|..|
Human   218 AIRRK-----VELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAG 277

  Fly   281 ---HGECV-KFVKELNVPTLVVGGGGYTLR 306
               ..|.| :.|:...||.|:|..|||..|
Human   278 IVKRDELVFRMVRGRRVPILMVTSGGYQKR 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	77/290 (27%)
HDAC11	NP_079103.2	Histone deacetylase	14..326		77/290 (27%)
		HDAC_classIV	35..319	CDD:212519	77/290 (27%)