DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC3 and hdac6

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_009302026.1	Gene:	hdac6 / 565482	ZFINID:	ZDB-GENE-030131-3232	Length:	1081	Species:	Danio rerio

Alignment Length:	414	Identity:	101/414 - (24%)
Similarity:	182/414 - (43%)	Gaps:	72/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYR-----PYK-ASAQDMLR 61
            |:|:...:|.      :.:.||..|||::      ..:..|:::::..     |.: |:.:::..
Zfish   449 DQRMMLHHNM------WDSHHPELPQRIS------RIFSRHEELRLLSRCHRIPARLATEEELAL 501

  Fly    62 FHSDEYIAYL---QQVTPQNI-----QCNSV-----AYTKYLAHFSVGEDCPVFDGLFDFCAMY- 112
            .||.::|:.:   :.:.|:::     :.||:     :||                     ||:.
Zfish   502 CHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYT---------------------CALLA 545

  Fly   113 TGASLEGAQKL--NHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIG---ILELLKYHPRVLYI 172
            .|:....||.:  ....:.:.|....| |||:|..|.|||:.|...:.   ...:.:...|||.:
Zfish   546 AGSCFNSAQAILTGQVRNAVAIVRPPG-HHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIV 609

  Fly   173 DIDVHHGDGVQEAFYLTDRVMTASFHKY-GNYFFPGTGDM-YE-IGAESGRYYSVNVPLKEG-ID 233
            |.|||||:|.|..|...|.|:..|.|:| ...|||.:.|. |: :|...||.|:||:|...| :.
Zfish   610 DWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMG 674

  Fly   234 DQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNV-PTLV 297
            |..|...|..::..|...:.|..:::..|.|:..||.||.|.::.:|:......:..|.. ..|:
Zfish   675 DPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLI 739

  Fly   298 VGGGGYTLRNVARCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLEL 362
            :..|||.|.:::...:..||:|:     .|.|.:  .|...|..|......:....|::..:..|
Zfish   740 ILEGGYNLTSISESMSMCTSMLL-----GDSPPS--LDHLTPLKTSATVSINNVLRAHAPFWSSL 797

  Fly   363 IVKHVYENLKMCQHSPSVQMVQTP 386
            .| ::.|:|::...||..:...||
Zfish   798 RV-NIPESLRLSLPSPKPKGKCTP 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	100/413 (24%)
hdac6	XP_009302026.1	HDAC6-dom1	76..412	CDD:212545
		HDAC6-dom2	448..798	CDD:212527	93/389 (24%)
		zf-UBP	999..1061	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810