Protein Alignment HDAC3 and HDAC8

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_001397654.1
• Gene: HDAC8 / 55869
• HGNCID: 13315
• Length: 403
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 145/350 - (41%)
• Similarity: 228/350 - (65%)
• Gaps: 20/350 - (5%)

  Fly    27 PQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVT-------PQNIQCNSV 84
            |:|.::.|||:..|.|||:|:|.:|..||.::|..||:|.|:.:||:|:       |.:|:
Human    35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIE---- 95

  Fly    85 AYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGF 149
                    :.:|.|||..:|:||:.|...||::..||.|......:.||||||.|||||.|||||
Human    96 --------YGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGF 152

  Fly   150 CYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEI 214
            ||:||.|:|||.|.:...|:||:|:|:||||||::||..|.:|||.|.||:...|||||||:.::
Human   153 CYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDV 217

  Fly   215 GAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTK 279
            |...|||||||||:::||.|:.|:|:.:.::..:...:.|.|:|||.|||::|||.:..|:::..
Human   218 GLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPV 282

  Fly   280 GHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLH 344
            |.|:|:|::.:..:.||::|||||.|.|.|||||:.|.:::.:.:.:::|..|::..:.||:.|.
Human   283 GIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLE 347

  Fly   345 PEINSRQDNANSKQYLELIVKHVYE 369
            ...:.|.|. |....::.|:.::.|
Human   348 ITPSCRPDR-NEPHRIQQILNYIKE 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	144/349 (41%)
HDAC8	NP_001397654.1	Histone deacetylase	14..324		135/300 (45%)
		HDAC8	16..371	CDD:212524	144/348 (41%)