DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC3 and hdac5

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_685659.5	Gene:	hdac5 / 557486	ZFINID:	ZDB-GENE-121219-3	Length:	1128	Species:	Danio rerio

Alignment Length:	439	Identity:	110/439 - (25%)
Similarity:	177/439 - (40%)	Gaps:	102/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYT 87
            ||....|:....|.:...||..:.:..|..||:..::...|| ||...|...:|.|.|  .:...
Zfish   713 HPEHAGRIQSVWSRLQETGLLGRCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQ--KLDSK 774

  Fly    88 KYLAHFSVGEDCPVFDGLFDFCAMYT-----GASLEGAQKLNHNHSDICINWSGGL--------- 138
            |.|...|.              .||.     |..::.....|..||...:..:.|.
Zfish   775 KLLGPISQ--------------KMYAVLPCGGIGVDSDTVWNEMHSSGAVRMAVGCVIELAFKVA 825

  Fly   139 ---------------HHAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDVHHGDGVQEA 185
                           |||::..|.|||:.|.:.| ..:||:..   .::|.||.|:|||:|.|:|
Zfish   826 AGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAI-TAKLLQQKLGVGKILIIDWDIHHGNGTQQA 889

  Fly   186 FYLTDRVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNVPLKEGID----DQSYFQVFKPI 244
            ||....|:..|.|:|  || ||||:|...|:|...|..::||:....|::    |..|...|:.:
Zfish   890 FYNDPNVLYISLHRYDDGN-FFPGSGAPEEVGVGPGEGFNVNIAWTGGVEPPMGDVEYLTAFRTV 953

  Fly   245 ISAIMDFYRPTAIVLQCGADSLAGDR--LGCFSLSTKGHGECVKFVKELNVPTLVVGG------- 300
            :..|.:.:.|..:::..|.|::.|.:  ||.::::.|..|...|.:.:|      .||
Zfish   954 VMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYNVTAKCFGHLTKQLMKL------AGGRVVLALE 1012

  Fly   301 GGYTLRNVARCWTHET---SLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLEL 362
            ||:.|  .|.|...|:   :||.|:  .|.||.|.......|..|           |:.::.:|:
Zfish  1013 GGHDL--TAICDASESCVEALLGDE--LNPLPLTVLQQKPCPKAT-----------ASLERVIEI 1062

  Fly   363 IVKHVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASDPDVRISVA 411
            ..|| :.:|:           :..|.|....|.:.|.|..:.|...::|
Zfish  1063 QSKH-WTSLQ-----------RLAPTVGQSLLDAQRREKDEADTLTAMA 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	103/414 (25%)
hdac5	XP_685659.5	ClassIIa_HDAC5_Gln-rich-N	94..181	CDD:197400
hdac5	XP_685659.5	HDAC5	688..1107	CDD:212531	110/439 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810