Protein Alignment HDAC3 and Hdac1

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_032254.1
• Gene: Hdac1 / 433759
• MGIID: 108086
• Length: 482
• Species: Mus musculus
• Alignment Length: 430
• Identity: 249/430 - (57%)
• Similarity: 334/430 - (77%)
• Gaps: 12/430 - (2%)

  Fly     2 TDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDE 66
            |.|:|.|:|:.||||::||.||||||.|:.:||:|::||||::||:||||:||:|::|.::|||:
Mouse     7 TKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    67 YIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDIC 131
            ||.:|:.:.|.|:.    .|:|.:..|:||||||||||||:||.:.||.|:..|.|||...:||.
Mouse    72 YIKFLRSIRPDNMS----EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIA 132

  Fly   132 INWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTAS 196
            :||:||||||||.||||||||||||:.||||||||.||||||||:||||||:||||.||||||.|
Mouse   133 VNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 197

  Fly   197 FHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQC 261
            |||||.| ||||||:.:|||..|:||:||.||::||||:||..:|||::|.:|:.::|:|:||||
Mouse   198 FHKYGEY-FPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQC 261

  Fly   262 GADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIEN 326
            |:|||:|||||||:|:.|||.:||:|||..|:|.|::||||||:||||||||:||::.:|.:|.|
Mouse   262 GSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPN 326

  Fly   327 DLPATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDV 389
            :||..:|:::|.|||.||  |   |...|.|:.:|||.|.:.::|||:|..|:|.|||...|.|.
Mouse   327 ELPYNDYFEYFGPDFKLHISP---SNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDA 388

  Fly   390 DLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429
            ..||  |..|:..|||.|||:...||.:..:.||.|.|::
Mouse   389 IPEE--SGDEDEEDPDKRISICSSDKRIACEEEFSDSDEE 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	231/385 (60%)
Hdac1	NP_032254.1	HDAC1	4..374	CDD:212534	226/374 (60%)
		Histone deacetylase	9..321		201/316 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		16/39 (41%)