Protein Alignment HDAC3 and hdac8

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_998596.1
• Gene: hdac8 / 406740
• ZFINID: ZDB-GENE-040426-2772
• Length: 378
• Species: Danio rerio
• Alignment Length: 353
• Identity: 148/353 - (41%)
• Similarity: 225/353 - (63%)
• Gaps: 20/353 - (5%)

  Fly    27 PQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVT-------PQNIQCNSV 84
            |.|.::.|||:..|||.|.|::.:|:.||.::|..||:|.|:.:|.:::       ||:
Zfish    36 PNRASMVHSLIEAYGLLKYMRVVKPHVASIEEMAVFHTDSYLQHLHKISQDGDNDDPQS------ 94

  Fly    85 AYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGF 149
                  |.|.:|.||||.:|:||:.|...||:|..||.|.....|:.|||:||.|||||.||||.
Zfish    95 ------ADFGLGYDCPVVEGIFDYAAAVGGATLTAAQNLLDGKCDVAINWAGGWHHAKKDEASGS 153

  Fly   150 CYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGNYFFPGTGDMYEI 214
            |||||.|:|||:|.:.:.||||:|:|:||||||::||..|.:|||.|.||:...|||||||:.:.
Zfish   154 CYVNDAVLGILKLREKYDRVLYVDVDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVTDT 218

  Fly   215 GAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTK 279
            |...||:|:||||.::|:.|..|.|.|..::..:...:.|.|:|:|.|||::|||.:..|:::..
Zfish   219 GLGKGRWYAVNVPFEDGVRDDRYCQTFTSVMQEVKALFNPEAVVMQLGADTMAGDPMCSFNMTPV 283

  Fly   280 GHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLH 344
            |..:|:.::....:|||::|||||.|.|.|||||:.|..::.|.:.:::|..|::..:.||::|.
Zfish   284 GVAKCLTYILGWELPTLLLGGGGYNLANTARCWTYLTGTVLGQTLSSEIPDHEFFTEYGPDYSLE 348

  Fly   345 PEINSRQDNANSKQYLELIVKHVYENLK 372
            ...:.|.|. |..|:||.::..:..|||
Zfish   349 ISPSCRPDR-NESQHLERVISTIKGNLK 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	148/353 (42%)
hdac8	NP_998596.1	Histone deacetylase	15..325		133/300 (44%)
		HDAC8	17..378	CDD:212524	148/353 (42%)