DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and HDAC1

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	246/428 - (57%)
Similarity:	330/428 - (77%)	Gaps:	12/428 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            :||.|:|::|:||::||.||||||.|:.:||:|::||||::||:||||:||:|.:|.:||||||:
  Fly     7 KRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYV 71

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            .:|:.:.|.|:.    .|.|.:..|:|||||||||||::||.:..|.|:..|.|||...|:||||
  Fly    72 RFLRSIRPDNMS----EYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICIN 132

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            |.||||||||.||||||||||||:|||||||||.|||||||||||||||:||||.||||||.|||
  Fly   133 WGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFH 197

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            |||.| ||||||:.:|||..|:||:||:||::|:||.:|..:|.||||.:|:.::|.|:||||||
  Fly   198 KYGEY-FPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGA 261

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||.|||||||:|:.||||:||:|||:.|:|.|:|||||||:|||:||||:|||:.:..:|.|:|
  Fly   262 DSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAVEIANEL 326

  Fly   329 PATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDL 391
            |..:|:::|.|||.||  |   |...|.|:.:|||.|...::|||:|..|:|.||:...|.|...
  Fly   327 PYNDYFEYFGPDFKLHISP---SNMTNQNTSEYLEKIKNRLFENLRMLPHAPGVQIQAIPEDAIN 388

  Fly   392 EELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429
            :|  |:.|:..|.|.|:..:|:||.:..:||:.|.:.:
  Fly   389 DE--SDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	233/385 (61%)
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	228/372 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458021
Domainoid	1	1.000	65	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.740