DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC3 and Hdac4

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_008765500.1	Gene:	Hdac4 / 363287	RGDID:	619979	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	115/453 - (25%)
Similarity:	185/453 - (40%)	Gaps:	86/453 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYT 87
            ||....|:....|.:...||..|.:..|..||:.:::...||:.: ..|....|.|.|
  Rat   687 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAH-TLLYGTNPLNRQ------- 743

  Fly    88 KYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGL-------------- 138
            |..:...:|....||..|  .|.   |..::.....|..||......:.|.
  Rat   744 KLDSKKLLGSLTSVFVRL--PCG---GVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELK 803

  Fly   139 ----------HHAKKFEASGFCYVNDIVIGILELLKYH---PRVLYIDIDVHHGDGVQEAFYLTD 190
                      |||::....||||.|.:.|. .:||:..   .::|.:|.|||||:|.|:|||...
  Rat   804 NGFAVVRPPGHHAEESTPMGFCYFNSVAIA-AKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDP 867

  Fly   191 RVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNVPLKEGID----DQSYFQVFKPIISAIM 249
            .|:..|.|:|  || ||||:|...|:|...|..::||:....|:|    |..|...|:.::..|.
  Rat   868 NVLYMSLHRYDDGN-FFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIA 931

  Fly   250 DFYRPTAIVLQCGADSLAG--DRLGCFSLSTKGHGECVKFVKELNVPTLVVG-GGGYTLRNVARC 311
            :.:.|..:::..|.|::.|  ..||.::||.|..|...|.:..|....:|:. .||:.|  .|.|
  Rat   932 NEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDL--TAIC 994

  Fly   312 WTHE--TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMC 374
            ...|  .|.|:..::|.           .|:..||     ::.|||:...:|.:         |.
  Rat   995 DASEACVSALLGNELEP-----------LPEKVLH-----QRPNANAVHSMEKV---------MG 1034

  Fly   375 QHSPSVQMVQ-TPPDVD---LEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQDQDKP 433
            .||...:.:| ..|.|.   :|..:...|||.......|::...|..:.::|  :...:::.|
  Rat  1035 IHSEYWRCLQRLSPTVGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSE--EEPMEEEPP 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	105/403 (26%)
Hdac4	XP_008765500.1	ClassIIa_HDAC4_Gln-rich-N	<99..160	CDD:197398
Hdac4	XP_008765500.1	HDAC4	661..1069	CDD:212530	111/423 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810