DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and HDAC6

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	110/457 - (24%)
Similarity:	200/457 - (43%)	Gaps:	67/457 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVSYFYNADV---GNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDE 66
            :|.|.|:|.:   .|.: ..|||.:|.|:...|.:..:|||.|:||...|..|:..::...|:..
  Fly   533 KVCYAYDAQMLLHCNLN-DTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRA 596

  Fly    67 YIAYLQQV---TPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKL--NHN 126
            ::..::::   .|:.:...:..|.....|          ...||...:..|..|:....:  ..:
  Fly   597 HVNTVRRLLGREPKELHDAAGIYNSVYLH----------PRTFDCATLAAGLVLQAVDSVLRGES 651

  Fly   127 HSDICINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDVHHGDGVQEAFYLT 189
            .|.|| |.....|||::....|||..|::.|.....::..  .|||.:|.|||||:|.|..|...
  Fly   652 RSGIC-NVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESN 715

  Fly   190 DRVMTASFHKY--GNYFFPG-TGDMYEIGAESGRYYSVNVPL-KEGIDDQSYFQVFKPIISAIMD 250
            .:|:..|.|:|  |::|..| .|:...:|..:||.::||:|. |:|:.|..|...|:.:|..|..
  Fly   716 PKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAY 780

  Fly   251 FYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVG-GGGYTLRNVARCWTH 314
            .:.|..:::..|.|:..||.||...::.:|:|....::..|....::|. .|||.:.:::...|.
  Fly   781 EFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTM 845

  Fly   315 ETSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIV-KHVYENLKMC---- 374
            .|..|:...:..                  |::     .|.:.|....:. :...|:|:.|
  Fly   846 CTKTLLGDPVPT------------------PQL-----GATALQKPPTVAFQSCVESLQQCLQVQ 887

  Fly   375 -QHSPSVQMV--QTPPDVDLEELRSNREEASDPDVR-ISVADEDKLVDAKNEFYDGDQDQDKPDS 435
             .|..|::.|  :.|.|..:.|  :|.|:.....:| ::::::|....|      |....|:||.
  Fly   888 RNHWRSLEFVGRRLPRDPVVGE--NNNEDFLTASLRHLNISNDDATAAA------GGLAGDRPDC 944

  Fly   436 AE 437
            .:
  Fly   945 GD 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	99/405 (24%)
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	95/391 (24%)
		zf-UBP	1007..1069	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840