DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and HDAC2

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001518.3	Gene:	HDAC2 / 3066	HGNCID:	4853	Length:	488	Species:	Homo sapiens

Alignment Length:	428	Identity:	247/428 - (57%)
Similarity:	332/428 - (77%)	Gaps:	12/428 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            ::|.|:|:.|:||::||.||||||.|:.:||:|::||||::||:||||:||:|::|.::||||||
Human    10 KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYI 74

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            .:|:.:.|.|:.    .|:|.:..|:||||||||||||:||.:.||.|:.||.|||...:|:.:|
Human    75 KFLRSIRPDNMS----EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVN 135

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            |:||||||||.||||||||||||:.||||||||.||||||||:||||||:||||.||||||.|||
Human   136 WAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFH 200

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            |||.| ||||||:.:|||..|:||:||.|:::||||:||.|:||||||.:|:.|:|:|:||||||
Human   201 KYGEY-FPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGA 264

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||:|||||||:|:.|||.:||:.||..|:|.|::||||||:||||||||:||::.:|.:|.|:|
Human   265 DSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNEL 329

  Fly   329 PATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDL 391
            |..:|:::|.|||.||  |   |...|.|:.:|:|.|.:.::|||:|..|:|.|||...|.|...
Human   330 PYNDYFEYFGPDFKLHISP---SNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVH 391

  Fly   392 EELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429
            |:  |..|:..|||.|||:...||.:....||.|.:.:
Human   392 ED--SGDEDGEDPDKRISIRASDKRIACDEEFSDSEDE 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	232/385 (60%)
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	225/371 (61%)
		Histone deacetylase	9..322		203/316 (64%)
		CobT2	<386..>479	CDD:226920	16/44 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..488		14/41 (34%)
		RPN2_C	<436..>488	CDD:375480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710