Protein Alignment HDAC3 and HDAC1

DIOPT Version :9

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_004955.2
• Gene: HDAC1 / 3065
• HGNCID: 4852
• Length: 482
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 248/430 - (57%)
• Similarity: 334/430 - (77%)
• Gaps: 12/430 - (2%)

  Fly     2 TDRRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDE 66
            |.|:|.|:|:.||||::||.||||||.|:.:||:|::||||::||:||||:||:|::|.::|||:
Human     7 TRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDD 71

  Fly    67 YIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDIC 131
            ||.:|:.:.|.|:.    .|:|.:..|:||||||||||||:||.:.||.|:..|.|||...:||.
Human    72 YIKFLRSIRPDNMS----EYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIA 132

  Fly   132 INWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTAS 196
            :||:||||||||.||||||||||||:.||||||||.||||||||:||||||:||||.||||||.|
Human   133 VNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 197

  Fly   197 FHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQC 261
            |||||.| ||||||:.:|||..|:||:||.||::||||:||..:|||::|.:|:.::|:|:||||
Human   198 FHKYGEY-FPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQC 261

  Fly   262 GADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIEN 326
            |:|||:|||||||:|:.|||.:||:|||..|:|.|::||||||:||||||||:||::.:|.:|.|
Human   262 GSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPN 326

  Fly   327 DLPATEYYDFFAPDFTLH--PEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDV 389
            :||..:|:::|.|||.||  |   |...|.|:.:|||.|.:.::|||:|..|:|.|||...|.|.
Human   327 ELPYNDYFEYFGPDFKLHISP---SNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDA 388

  Fly   390 DLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQD 429
            ..||  |..|:..|||.|||:...||.:..:.||.|.:::
Human   389 IPEE--SGDEDEDDPDKRISICSSDKRIACEEEFSDSEEE 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	231/385 (60%)
HDAC1	NP_004955.2	HDAC1	4..374	CDD:212534	226/374 (60%)
		Histone deacetylase	9..321		201/316 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		15/39 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710