DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and hos2

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_594079.1	Gene:	hos2 / 2543643	PomBaseID:	SPAC3G9.07c	Length:	434	Species:	Schizosaccharomyces pombe

Alignment Length:	418	Identity:	215/418 - (51%)
Similarity:	292/418 - (69%)	Gaps:	13/418 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            :||:|..:..|||:|||..|||||.|:.:|:.|||.||||.||.::.|..|:..:|..||.::|:
pombe    26 KRVTYHLDEQVGNYHYGDKHPMKPHRITITNHLVMGYGLHNKMSVFSPRMATFGEMSEFHREDYL 90

  Fly    69 AYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICIN 133
            .:|::|||.|.:    .:......|::|:|||||||.::|.....||||:.::||....:||.||
pombe    91 DFLKRVTPDNAE----QFADKFQQFNIGDDCPVFDGTYEFSQRSAGASLDASRKLVQGQTDIAIN 151

  Fly   134 WSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFH 198
            |||||||||:.||||||||||||:.||.:|::.|||||||||:|||||||:|||.:|||:|.|||
pombe   152 WSGGLHHAKRGEASGFCYVNDIVLAILNMLRFFPRVLYIDIDIHHGDGVQQAFYESDRVLTVSFH 216

  Fly   199 KYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQCGA 263
            ||...|||.||:..|.|.:.|:|:::||||::||.|:.|..:||.||...::.::|:||||||||
pombe   217 KYNGDFFPATGNFDENGVKGGKYFALNVPLEDGIGDEQYTSLFKSIIEPTINTFQPSAIVLQCGA 281

  Fly   264 DSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIENDL 328
            |||..||||.|:||...|||||:|.:..|:|.|||||||||||||||.|.:|||:.|::.|.::|
pombe   282 DSLGYDRLGVFNLSIHAHGECVRFTRSFNIPMLVVGGGGYTLRNVARAWCYETSICVNEQIPSEL 346

  Fly   329 P-ATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVDLE 392
            | .|.||:|||||:||||.:.::.:|.|:.:.||.:.....|.|:....:|||||.|.|||
pombe   347 PRETLYYEFFAPDYTLHPRLTTKIENKNTPKALEDLRIRALEQLRYLGGAPSVQMQQIPPD---- 407

  Fly   393 ELRSNREEASDPDVRISVADEDKLVDAK 420
             |..:.||   .|.|::....||.||.:
pombe   408 -LTGHLEE---EDERLNDEYLDKAVDVR 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	204/384 (53%)
hos2	NP_594079.1	PTZ00063	25..426	CDD:240251	211/411 (51%)
hos2	NP_594079.1	HDAC_Hos2	28..337	CDD:212540	174/312 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	65	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62154
OrthoFinder	1	1.000	-	-		FOG0000617
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780