Protein Alignment HDAC3 and hda-5

DIOPT Version :10

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_741051.1
• Gene: hda-5 / 174811
• WormBaseID: WBGene00009663
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 332
• Identity: 77/332 - (23%)
• Similarity: 137/332 - (41%)
• Gaps: 59/332 - (17%)

  Fly   139 HHAKKFEASGFCYVNDIVIG---ILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKY 200
            ||:....|.|:|..|::.|.   .:|.|:. .:|..:|.|.|.|:|..::.....|:...|||
 Worm   133 HHSYGKVAQGYCIFNNVAIAAKYAIEKLEV-KKVAIVDFDYHAGNGTYQSVKDESRIHLTSFH-- 194

  Fly   201 GNY---FFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQ-SYFQVFKPIISAIMDFYRPTAIVLQC 261
            |::   |:|.:.| |:....|..  ::.|||...::.: .|..||..::..:::.::|..|::..
 Worm   195 GHHFGAFWPFSRD-YDYATNSQN--TLFVPLNGTMNSEGDYVSVFHHVLLPMLEQFQPELILISA 256

  Fly   262 GADSLAGDRLGCFSLSTK--GHGECVKFVKELNVP--TLVVGGGGYTLRNVARCWTHETSLLVDQ 322
            |.||...|.:..|....|  |:|...:.:.:: .|  .|.:..|||...|    :|...|::|..
 Worm   257 GFDSGYYDVMMEFGQGVKAHGYGHMARLLSQI-CPGKILAILEGGYHPYN----YTESASMMVRG 316

  Fly   323 DIENDLPATEYYDFFAPDFTLHPEINSRQD--NANSKQYLELIVKHVYENLKMCQHS------PS 379
            .:...||..:     .|:......:.:..:  |.:|:.|.:|     .|.||:.:|.      |.
 Worm   317 LLNLPLPRLD-----IPERISGALLETTWNILNHHSEWYPKL-----GERLKLLEHQQKELGLPQ 371

  Fly   380 VQMVQTP----------PDVDLEELRSNRE---EASDPDVRISVADEDKLVDAKNEFYDGDQDQD 431
            ....||.          .|:....:...||   |.||..|.:.....|:.:. :.||     ..:
 Worm   372 FAFDQTMFLGEKMRKMYDDMKKHRIVRTREWFPEMSDDQVAVCKQKIDEYIQ-EYEF-----TSE 430

  Fly   432 KPDSAES 438
            .|..:||
 Worm   431 HPTPSES 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	64/277 (23%)
hda-5	NP_741051.1	HDAC10_HDAC6-dom1	19..350	CDD:212526	55/232 (24%)