Protein Alignment HDAC3 and hda-2

DIOPT Version :9

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: NP_495678.1
• Gene: hda-2 / 174285
• WormBaseID: WBGene00001835
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 436
• Identity: 211/436 - (48%)
• Similarity: 286/436 - (65%)
• Gaps: 12/436 - (2%)

  Fly     4 RRVSYFYNADVGNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYI 68
            |.|:|:|:.|||:||||..||||||||.|.:.||::|.:.|.|.:....|..|.|:..||:::|:
 Worm    29 RNVAYYYHKDVGHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAADISVFHTEDYV 93

  Fly    69 AYLQQVTPQNIQCNSVAYT---KYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDI 130
            .:||.|||:      :..|   ..|..|::|||||:|.||:|:|.:|.|.|:|||::|||..:||
 Worm    94 NFLQTVTPK------LGLTMPDDVLRQFNIGEDCPIFAGLWDYCTLYAGGSVEGARRLNHKMNDI 152

  Fly   131 CINWSGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTA 195
            .|||.||||||||.||||||||||||:|||||||||.||||||||:||||||||||..:|||||.
 Worm   153 VINWPGGLHHAKKSEASGFCYVNDIVLGILELLKYHKRVLYIDIDIHHGDGVQEAFNNSDRVMTV 217

  Fly   196 SFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTAIVLQ 260
            |||::|.| |||:|.:.:.|...|:|:::||||...|.|:.|.::|:.:||.:.:.:.|.|||||
 Worm   218 SFHRFGQY-FPGSGSIMDKGVGPGKYFAINVPLMAAIRDEPYLKLFESVISGVEENFNPEAIVLQ 281

  Fly   261 CGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYTLRNVARCWTHETSLLVDQDIE 325
            ||:|||..||||.|:||...|...||:||.|..|.:|:||||||||||||||..||.:::...::
 Worm   282 CGSDSLCEDRLGQFALSFNAHARAVKYVKSLGKPLMVLGGGGYTLRNVARCWALETGVILGLRMD 346

  Fly   326 NDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVKHVYENLKMCQHSPSVQMVQTPPDVD 390
            :::|.|..|..:.....|.|.:..:.::|||..||..|.|.....|:|.:.:||||| |....:.
 Worm   347 DEIPGTSLYSHYFTPRLLRPNLVPKMNDANSAAYLASIEKETLACLRMIRGAPSVQM-QNIVGIR 410

  Fly   391 LEELRSNRE-EASDPDVRISVADEDKLVDAKNEFYDGDQDQDKPDS 435
            |:|:....| |......:.|:..|...|..|.|.....::..||.|
 Worm   411 LDEIEQIEENERLQKSSKSSIEYEVGKVSEKMEEECFVEEDSKPPS 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	199/386 (52%)
hda-2	NP_495678.1	PTZ00063	28..430	CDD:240251	203/408 (50%)
		Arginase_HDAC	29..406	CDD:302587	199/384 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62154
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100248
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.680