DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC3 and Hdac6

DIOPT Version :9

Sequence 1:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001123888.1	Gene:	Hdac6 / 15185	MGIID:	1333752	Length:	1149	Species:	Mus musculus

Alignment Length:	454	Identity:	106/454 - (23%)
Similarity:	174/454 - (38%)	Gaps:	108/454 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQ--------------- 72
            ||..|||:......:...||..:..|.....|...::|..||.||:.:|:
Mouse   499 HPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGA 563

  Fly    73 -----QVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICI 132
                 .:.|....|         |..:.|..|.:.:      |:.:|..|.|          |.:
Mouse   564 NFDSIYICPSTFAC---------AKLATGAACRLVE------AVLSGEVLNG----------IAV 603

  Fly   133 NWSGGLHHAKKFEASGFCYVNDIVIGI--LELLKYHP-RVLYIDIDVHHGDGVQEAFYLTDRVMT 194
            ....| |||:...|.|||:.|.:.:..  .:::.... |:|.:|.|||||:|.|..|.....|:.
Mouse   604 VRPPG-HHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHGNGTQHIFEDDPSVLY 667

  Fly   195 ASFHKYG-NYFFP--GTGDMYEIGAESGRYYSVNVPLK-EGIDDQSYFQVFKPIISAIMDFYRPT 255
            .|.|:|. ..|||  ..|...::|.::|..::||||.. ..:.|..|...:..::..|...:.|.
Mouse   668 VSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVLPIAYEFNPE 732

  Fly   256 AIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGG-------GGYTLRNV----A 309
            .:::..|.|:..||.||...::.:|:......:..|      .||       |||.|.::    |
Mouse   733 LVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGL------AGGRIILILEGGYNLASISESMA 791

  Fly   310 RCWTHETSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNA----------NSKQYLELIV 364
            .| ||  |||.|.               .|..||   :...|..|          :.|.:..|.:
Mouse   792 AC-TH--SLLGDP---------------PPQLTL---LRPPQSGALVSISEVIQVHRKYWRSLRL 835

  Fly   365 KHVYENLKMCQHSPSV--QMVQTPPDVDLEELRSNREEASDPDVRISVA----DEDKLVDAKNE 422
            ..: |:.:.|..|..|  ::..|...|..:|:.:.:.:..:..||.::|    .|..|..||::
Mouse   836 MKM-EDKEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSK 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	97/414 (23%)
Hdac6	NP_001123888.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		Histone deacetylase 1	87..403
		Arginase_HDAC	98..434	CDD:418394
		Histone deacetylase 2	481..799		83/334 (25%)
		HDAC6-dom2	484..834	CDD:212527	91/387 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..975
		zf-UBP	1067..1129	CDD:396634
		Ubiquitin binding. /evidence=ECO:0000250\|UniProtKB:Q9UBN7	1088..1090
		Ubiquitin binding. /evidence=ECO:0000250\|UniProtKB:Q9UBN7	1116..1123
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810