Protein Alignment HDAC3 and HDAC5

DIOPT Version :9

• Sequence 1: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Sequence 2: XP_016879477.1
• Gene: HDAC5 / 10014
• HGNCID: 14068
• Length: 1161
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 106/429 - (24%)
• Similarity: 164/429 - (38%)
• Gaps: 110/429 - (25%)

  Fly     3 DRRVSYFYNADV-------------GNFHYGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKA 54
            |:.|.:.:...|             ||.|.   ||....|:....|.:...||..|.:..|..||
Human   713 DQPVKHLFTTGVVYDTFMLKHQCMCGNTHV---HPEHAGRIQSIWSRLQETGLLSKCERIRGRKA 774

  Fly    55 SAQDMLRFHSDEYIAYLQQVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAMYT-----G 114
            :..::...|| ||...|...:|.|.|  .:...|.|...|.              .||.     |
Human   775 TLDEIQTVHS-EYHTLLYGTSPLNRQ--KLDSKKLLGPISQ--------------KMYAVLPCGG 822

  Fly   115 ASLEGAQKLNHNHSDICINWSGGL------------------------HHAKKFEASGFCYVNDI 155
            ..::.....|..||...:..:.|.                        |||::..|.|||:.|.:
Human   823 IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 887

  Fly   156 VIGILELLKYH---PRVLYIDIDVHHGDGVQEAFYLTDRVMTASFHKYGN-YFFPGTGDMYEIGA 216
            .| ..:||:..   .:||.:|.|:|||:|.|:|||....|:..|.|:|.| .||||:|...|:|.
Human   888 AI-TAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGG 951

  Fly   217 ESGRYYSVNVPLKEGID----DQSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAG--DRLGCFS 275
            ..|..|:|||....|:|    |..|...|:.::..|...:.|..:::..|.|::.|  ..||.:|
Human   952 GPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYS 1016

  Fly   276 LSTKGHGECVKFVKELNVPTLVVGG-------GGYTLRNVARCWTHE--TSLLVDQDIENDLPAT 331
            ::.:..|...:.:..|      .||       ||:.|  .|.|...|  .|.|:..:::
Human  1017 VTARCFGHLTRQLMTL------AGGRVVLALEGGHDL--TAICDASEACVSALLSVELQ------ 1067

  Fly   332 EYYDFFAPDFTLHPEINSRQDNANSKQYLELIV----KH 366
                      .|...:..::.|.|:...||.::    ||
Human  1068 ----------PLDEAVLQQKPNINAVATLEKVIEIQSKH 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	105/428 (25%)
HDAC5	XP_016879477.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810