DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bem46 and Acot5

DIOPT Version :9

Sequence 1:	NP_477372.1	Gene:	Bem46 / 44441	FlyBaseID:	FBgn0025109	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_663419.3	Gene:	Acot5 / 217698	MGIID:	2384969	Length:	421	Species:	Mus musculus

Alignment Length:	260	Identity:	52/260 - (20%)
Similarity:	89/260 - (34%)	Gaps:	87/260 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 MVEYRGYGLSTGVPTERGLVTDARA---------AIDYLHTRHD-------LDHSQLI-----LF 184
            ::|||. .|..|    :|....|.|         .||.||..:.       |.|.|:.     |.
Mouse   170 LLEYRA-SLLAG----KGFAVMALAYYKYDDLPKVIDILHLEYFEEAVTYLLSHPQVKGPGVGLL 229

  Fly   185 GRSLGGAVVVDVAADTVYGQKLMCAIVENTFS------------SIPEMAVELVHPAV-----KY 232
            |.|.|..:.:.:|:   :.:.:..|:|.|..:            |:|.:.:.|....|     |.
Mouse   230 GISKGAELSLSMAS---FLKGITAAVVINGATVNVISTLYYKEESLPGLGMHLERIKVTKDGFKD 291

  Fly   233 IPNLLFKN------KYHSMSKIGKCSVPFLFISGLADNLVPPRMMRALYTK--------CGSEIK 283
            |.::|  |      ...|:..:.:....|||:.|..|:    ......|.:        .|.|..
Mouse   292 IIDIL--NVPLEAPDQKSLIPLERSDTAFLFLVGQDDH----NWKSEFYAREASKRLQAHGKEKP 350

  Fly   284 RLLEFPGGSHN-----DTWIV---DGYYQ---AIGGFLAELQQQPLLKAPEKSNVWVELE---HK 334
            :::.:|...|:     ..|.:   ..|:.   .:||       :|...|..:.:.|..|:   ||
Mouse   351 QIVCYPKTGHHIEPPYIPWSIAAPHSYFDKPILLGG-------EPRAHAMAQVDAWQRLQTFFHK 408

Fly 335 334
Mouse 409 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bem46	NP_477372.1	FrsA	72..305	CDD:223999	44/226 (19%)
Bem46	NP_477372.1	Abhydrolase_5	110..294	CDD:289465	41/204 (20%)
Acot5	NP_663419.3	Bile_Hydr_Trans	16..137	CDD:398442
		Abhydrolase	145..>259	CDD:419691	23/96 (24%)
		BAAT_C	204..412	CDD:400960	41/221 (19%)
		Microbody targeting signal. /evidence=ECO:0000255	419..421
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1073
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900