DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTu1 and TUF1

DIOPT Version :9

Sequence 1:	NP_001163144.1	Gene:	mEFTu1 / 44438	FlyBaseID:	FBgn0024556	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_014830.1	Gene:	TUF1 / 854359	SGDID:	S000005713	Length:	437	Species:	Saccharomyces cerevisiae

Alignment Length:	439	Identity:	257/439 - (58%)
Similarity:	324/439 - (73%)	Gaps:	14/439 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SARMLRMAGATATSTACKDWQRNGLLAAPRTGNMQQYLREYANEKKVFERTKPHCNVGTIGHVDH 93
            ||.:.|:...||...:.|..:.:.:::  ||  ..|....||   ..|:|:|||.|:||||||||
Yeast     2 SALLPRLLTRTAFKASGKLLRLSSVIS--RT--FSQTTTSYA---AAFDRSKPHVNIGTIGHVDH 59

  Fly    94 GKTTLTAAITKVLADKQLAESKKYNEIDNAPEEKARGITINVAHVEYQTETRHYGHTDCPGHADY 158
            |||||||||||.||.|..|....|..||.||||:||||||:.|||||:|..|||.|.||||||||
Yeast    60 GKTTLTAAITKTLAAKGGANFLDYAAIDKAPEERARGITISTAHVEYETAKRHYSHVDCPGHADY 124

  Fly   159 IKNMITGTAQMDGAILVVAATDGAMPQTREHMLLAKQIGIDHIVVFINKVDAADE-EMVDLVEME 222
            |||||||.|||||||:|||||||.|||||||:|||:|:|:.|||||:||||..|: ||::|||||
Yeast   125 IKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQHIVVFVNKVDTIDDPEMLELVEME 189

  Fly   223 IRELLTEMGYDGDKIPVVKGSALCALEDKSPEIGKEAILKLLQEVDSFIPTPVRELDKPFLLPVE 287
            :||||.|.|:|||..|::.||||||||.:.||||::||:|||..||.:||||.|:|:||||:|||
Yeast   190 MRELLNEYGFDGDNAPIIMGSALCALEGRQPEIGEQAIMKLLDAVDEYIPTPERDLNKPFLMPVE 254

  Fly   288 NVYSIPGRGTVVTGRLERGVVKKGMECEFVGYNKV-LKSTVTGVEMFHQILEEAQAGDQLGALVR 351
            :::||.|||||||||:|||.:|||.|.|.||:|.. ||:||||:|||.:.|:.|.|||..|.|:|
Yeast   255 DIFSISGRGTVVTGRVERGNLKKGEELEIVGHNSTPLKTTVTGIEMFRKELDSAMAGDNAGVLLR 319

  Fly   352 GVKRDDIKRGMVMCKPGSVKALDQLEAQVYILSKDEGGRTKPFMSFIQLQMFSRTWDCAVQVQIP 416
            |::||.:|||||:.|||:|||..::.|.:|||||:||||...|....:.|||.||.|..|.::.|
Yeast   320 GIRRDQLKRGMVLAKPGTVKAHTKILASLYILSKEEGGRHSGFGENYRPQMFIRTADVTVVMRFP 384

  Fly   417 ----DKEM-VMPGEDTKLILRLIRPMVLEQGQRFTLRDGNLTLGTGVVT 460
                |..| ||||::.::...||.|..||.||||.:|:|..|:|||::|
Yeast   385 KEVEDHSMQVMPGDNVEMECDLIHPTPLEVGQRFNIREGGRTVGTGLIT 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTu1	NP_001163144.1	PRK00049	73..463	CDD:234596	246/395 (62%)
		EF_Tu	81..274	CDD:206671	138/193 (72%)
		EFTU_II	282..368	CDD:293898	53/86 (62%)
		mtEFTU_III	371..462	CDD:294005	43/95 (45%)
TUF1	NP_014830.1	PRK00049	40..437	CDD:234596	246/394 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346102
Domainoid	1	1.000	289	1.000	Domainoid score	I236
eggNOG	1	0.900	-	-		E1_COG0050
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2490
Inparanoid	1	1.050	490	1.000	Inparanoid score	I217
Isobase	1	0.950	-	0	Normalized mean entropy	S366
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002097
OrthoInspector	1	1.000	-	-		oto100293
orthoMCL	1	0.900	-	-		OOG6_100780
Panther	1	1.100	-	-	LDO	PTHR43721
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R370
SonicParanoid	1	1.000	-	-		X2038
TreeFam	1	0.960	-	-
	14	13.730